{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:40:55Z","timestamp":1790106055927,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,22]],"date-time":"2023-01-22T00:00:00Z","timestamp":1674345600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Delirium is highly prevalent in hospitalised older adults, under\u2010diagnosed and associated with poor outcomes. We aim to determine (i) association of frailty measured using Hospital Frailty Risk Score (HFRS) with delirium, (ii) impact of delirium on mortality, 30\u2010days readmission, extended length of stay (eLOS) and cost (eCOST).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study was conducted on 902 older adults \u226575\u00a0years discharged from an academic tertiary hospital between March and September 2021. Data was obtained from hospital administrative database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Delirium was prevalent in 39.1%, 58.1% were female with mean age 85.3\u00a0\u00b1\u00a06.2\u00a0years. Patients with delirium were significantly older, had higher HFRS, pneumonia, urinary tract infection (UTI), E.coli and <jats:italic>Klebsiella<\/jats:italic> infection, constipation, dehydration, stroke and intracranial bleed, with comorbidities including dementia, diabetes, hypertension, hyperlipidaemia and chronic kidney disease. In\u2010hospital mortality, 30\u2010days mortality, 30\u2010days readmission, median LOS and cost was significantly higher. Delirium was significantly associated with at least intermediate frailty (OR\u00a0=\u00a03.52; CI\u00a0=\u00a02.48\u20134.98), dementia (OR\u00a0=\u00a02.39; CI\u00a0=\u00a01.61\u20133.54), UTI (OR\u00a0=\u00a01.95; CI\u00a0=\u00a01.29\u20132.95), constipation (OR\u00a0=\u00a02.49; CI\u00a0=\u00a01.43\u20134.33), <jats:italic>Klebsiella<\/jats:italic> infection (OR\u00a0=\u00a03.06; CI\u00a0=\u00a01.28\u20137.30), dehydration (OR\u00a0=\u00a02.01; CI\u00a0=\u00a01.40 \u2010 2.88), 30\u2010day mortality (OR\u00a0=\u00a02.52; CI\u00a0=\u00a01.42\u20134.47), 30\u2010day readmission (OR\u00a0=\u00a02.18; CI\u00a0=\u00a01.36\u20133.48), eLOS (OR\u00a0=\u00a01.80; CI\u00a0=\u00a01.30\u20132.49) and eCOST (OR\u00a0=\u00a01.67; CI\u00a0=\u00a01.20\u20132.35).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Delirium was highly prevalent in older inpatients, and associated with dementia, frailty, increased cost, LOS, 30\u2010day readmissions and mortality. Hospital Frailty Risk Score had robust association with delirium and can be auto\u2010populated from electronic medical records. Prospective studies are needed on multicomponent delirium preventive measures in high\u2010risk groups identified by HFRS in acute care settings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.5872","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T07:48:40Z","timestamp":1673509720000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Delirium is significantly associated with hospital frailty risk score derived from administrative data"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1649-3335","authenticated-orcid":false,"given":"Zhiying","family":"Lim","sequence":"first","affiliation":[{"name":"Division of Geriatric Medicine Department of Medicine National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Ling","sequence":"additional","affiliation":[{"name":"Division of 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