{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T03:14:00Z","timestamp":1776222840532,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 107\u20102320\u2010B\u2010006\u2010035"],"award-info":[{"award-number":["MOST 107\u20102320\u2010B\u2010006\u2010035"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Epidemiological data regarding antipsychotic initiation in elderly patients with stroke are limited. We aimed to investigate the incidence, prescription patterns and determinants of antipsychotic initiation in elderly patients with stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study to identify patients aged above 65\u00a0years who had been admitted for stroke from the National Health Insurance Database (NHID). The index date was defined as the discharge date. The incidence and prescription pattern of antipsychotics were estimated using the NHID. To evaluate the determinants of antipsychotic initiation, the cohort identified from the NHID was linked to the Multicenter Stroke Registry (MSR). Demographics, comorbidities and concomitant medications were obtained from the NHID. Information including smoking status, body mass index, stroke severity and disability was retrieved by linking to the MSR. The outcome was antipsychotic initiation after the index date. Hazard ratios for antipsychotic initiation were estimated using the multivariable Cox model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In terms of prognosis, the first 2\u00a0months after a stroke was the highest\u2010risk period for antipsychotic use. A high burden of coexisting diseases carried an increased risk of antipsychotic use; in particular, chronic kidney disease (CKD) had the highest adjusted hazard ratio (aHR\u00a0=\u00a01.73; 95% CI 1.29\u20132.31) as compared with other risk factors. Furthermore, stroke severity and disability were significant risk factors for antipsychotic initiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study indicated that elderly stroke patients with chronic medical conditions, particularly CKD, and a higher stroke severity and disability were at greater risk of psychiatric disorders during the first 2\u00a0months after a stroke.<\/jats:p><jats:p>Clinical trial registration: NA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.5892","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T19:02:21Z","timestamp":1677006141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Incidence, prescription patterns and risk factors of antipsychotic initiation in elderly stroke survivors"],"prefix":"10.1002","volume":"38","author":[{"given":"Chien\u2010Chou","family":"Su","sequence":"first","affiliation":[{"name":"Clinical Innovation and Research Center National Cheng Kung University Hospital College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yea\u2010Huei Kao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy National Cheng Kung University Hospital College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"Institute of Clinical Pharmacy and Pharmaceutical Sciences College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"School of Pharmacy College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"Health Outcome Research Center National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Lan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy National Cheng Kung University Hospital College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"Institute of Clinical Pharmacy and Pharmaceutical Sciences College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"School of Pharmacy College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"Health Outcome Research Center National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward Chia\u2010Cheng","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Pharmacy National Cheng Kung University Hospital College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"Institute of Clinical Pharmacy and Pharmaceutical Sciences College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"School of Pharmacy College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"Health Outcome Research Center National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010Yang","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Neurology Tainan Sin Lau Hospital  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Hung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huey\u2010Juan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology Chi Mei Medical Center  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng\u2010Feng","family":"Sung","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Internal Medicine Ditmanson Medical Foundation Chiayi Christian Hospital  Chiayi Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Taiwan Landseed Hospital  Taoyuan Taiwan"},{"name":"Department of Neurology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(14)70016\u2010x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102017\u2010317327"},{"key":"e_1_2_12_4_1","volume-title":"Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications","author":"Stahl SM","year":"2013"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2020.08.025"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2021.05.025"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/clep.S196293"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.110.936526"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.07.033"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2014.16.2.59"},{"key":"e_1_2_12_11_1","volume-title":"Age Standardization of Rates: A New WHO Standard","author":"Ahmad OB","year":"2001"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.11030347"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.112.122499"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.3018"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2012.00073"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756285617712979"},{"key":"e_1_2_12_17_1","unstructured":"Institute for Health Metrics and Evaluation.Global burden of disease (GBD). Accessed February 7 2022.https:\/\/vizhub.healthdata.org\/gbd\u2010compare\/"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338135"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00932"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000002527"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.131"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2015.01.009"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010014\u20107242\u2010x"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww288"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.5892","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/gps.5892","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.5892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:32:52Z","timestamp":1692577972000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.5892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1002\/gps.5892"],"URL":"https:\/\/doi.org\/10.1002\/gps.5892","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"2022-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e5892"}}