{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:59:57Z","timestamp":1787702397042,"version":"build-2784847793"},"reference-count":62,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recent research suggests that abnormalities in the habenula (HB), a core area of the brain that transmits reward information, may be a determinant of depression. However, it is not clear whether the functional connectivity (FC) pattern of the mild cognitive impairment (MCI) with and without depression symptoms is abnormal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this study, we used resting\u2010state functional magnetic resonance imaging (fMRI) to examine the FC pattern of the HB in MCI patients with depression symptoms (D\u2010MCI). We acquired fMRI data from 54 subjects on a 3T MRI. Subjects collected included 16 patients with D\u2010MCI, 18 patients with MCI with no depression, and 20 healthy controls. One way ANCOVA and post hoc\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test were used to compare the difference in FC strength between the three groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The D\u2010MCI group had altered FC between the left HB and the right superior temporal gyrus, right inferior frontal gyrus\/opercular part, and right middle frontal gyrus. The D\u2010MCI group had increased FC between the right HB and precuneus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results suggest that the dysfunction of the HB\u2013Default model network might be involved in the neural mechanism underlying depression in MCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/gps.5910","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T09:55:31Z","timestamp":1681120531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Abnormal functional connectivity of the habenula in mild cognitive impairment patients with depression symptoms revealed by resting\u2010state functional magnetic resonance imaging"],"prefix":"10.1002","volume":"38","author":[{"given":"Yungang","family":"Cao","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children's Hospital Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglian","family":"Xia","sequence":"additional","affiliation":[{"name":"Tongde Hospital of Zhejiang Province  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Tongde Hospital of Zhejiang Province  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Hou","sequence":"additional","affiliation":[{"name":"Tongde Hospital of Zhejiang Province  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwei","family":"Guo","sequence":"additional","affiliation":[{"name":"Tongde Hospital of Zhejiang Province  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuquan","family":"Wei","sequence":"additional","affiliation":[{"name":"Tongde Hospital of Zhejiang Province  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1580-6942","authenticated-orcid":false,"given":"Xiaozheng","family":"Liu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children's Hospital Wenzhou Medical University  Wenzhou Zhejiang 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