{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T19:03:40Z","timestamp":1769108620789,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T00:00:00Z","timestamp":1681603200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1138968"],"award-info":[{"award-number":["GNT1138968"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare survival and risk factors associated with mortality in common young\u2010onset dementias (YOD) including Huntington's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study included inpatients from an Australian specialist neuropsychiatry service, over 20\u00a0years. Dementia diagnoses were based on consensus criteria and Huntington's disease (HD) was confirmed genetically. Mortality and cause of death were determined using linkage to the Australian Institute of Health and Welfare National Death Index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 386 individuals with YOD included. The dementia types included frontotemporal dementia (FTD) (24.5%), HD (21.2%) and Alzheimer's disease (AD) (20.5%). 63% (<jats:italic>n<\/jats:italic>\u00a0=\u00a0243) individuals had died. The longest median survival was for those who had HD, 18.8\u00a0years from symptom onset and with a reduced mortality risk compared to AD and FTD (hazard ratio 0.5). Overall, people with YOD had significantly increased mortality, of 5\u20138 times, compared to the general population. Females with a YOD had higher standardised mortality ratio compared to males (9.3 vs. 4.9) overall. The most frequent cause of death in those with HD was reported as HD, with other causes of death in the other YOD\u2010subtypes related to dementia and mental\/behavioural disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This is the first Australian study to investigate survival and risk factors of mortality in people with YOD. YOD has a significant risk of death compared to the general population. Our findings provide useful clinical information for people affected by YOD as well as future planning and service provision.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.5913","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T05:26:16Z","timestamp":1681709176000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Survival in Huntington\u2019s disease and other young\u2010onset dementias"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4953-4500","authenticated-orcid":false,"given":"Samantha M.","family":"Loi","sequence":"first","affiliation":[{"name":"Neuropsychiatry NorthWestern Mental Health, Melbourne Health Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Department of Psychiatry The University of Melbourne  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paraskevi","family":"Tsoukra","sequence":"additional","affiliation":[{"name":"Department of Neurology Evaggelismos Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Sun","sequence":"additional","affiliation":[{"name":"Neuropsychiatry NorthWestern Mental Health, Melbourne Health Royal Melbourne Hospital  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhibin","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Wibawa","sequence":"additional","affiliation":[{"name":"Neuropsychiatry NorthWestern Mental Health, Melbourne Health Royal Melbourne Hospital  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria di","family":"Biase","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The University of Melbourne  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Farrand","sequence":"additional","affiliation":[{"name":"Neuropsychiatry NorthWestern Mental Health, Melbourne Health Royal Melbourne Hospital  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhamidhu","family":"Eratne","sequence":"additional","affiliation":[{"name":"Neuropsychiatry NorthWestern Mental Health, Melbourne Health Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Department of Psychiatry The University of Melbourne  Parkville Victoria Australia"},{"name":"Florey Institute of Neuroscience and Mental Health  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Kelso","sequence":"additional","affiliation":[{"name":"Neuropsychiatry NorthWestern Mental Health, Melbourne Health Royal Melbourne Hospital  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Medicine Royal Melbourne Hospital  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Walterfang","sequence":"additional","affiliation":[{"name":"Neuropsychiatry NorthWestern Mental Health, Melbourne Health Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Department of Psychiatry The University of Melbourne  Parkville Victoria Australia"},{"name":"Florey Institute of Neuroscience and Mental Health  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Velakoulis","sequence":"additional","affiliation":[{"name":"Neuropsychiatry NorthWestern Mental Health, Melbourne Health Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Department of Psychiatry The University of Melbourne  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(10)70159\u20109"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5691"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25075"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/306234a0"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910\u2010011\u20100215\u2010x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.12.018"},{"key":"e_1_2_9_8_1","volume-title":"Deaths Due to Dementia","author":"Australian Institute of Health and Welfare","year":"2022"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5424"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.13099"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/s1041610219000152"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102018\u2010318820"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.14802\/jmd.16022"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12502"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/00048674211041003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1039856221992643"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr179"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0b013e31821103e6"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/j.1440\u20101614.2006.01923.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/s1041610211002924"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3233\/jhd\u2010170247"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102019\u2010320646"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.010"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000008387"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(19)30394\u20101"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443205"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.16090168"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102011\u2010301883"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1212\/nxg.0000000000000507"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.31887\/dcns.2016.18.4\/cepperson"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010022\u201006185\u20107"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3233\/jhd\u2010170270"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.3094"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.5913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T14:19:19Z","timestamp":1699021159000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.5913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/gps.5913"],"URL":"https:\/\/doi.org\/10.1002\/gps.5913","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"2022-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e5913"}}