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We compared 1\u2010year change in cognition and QOL by diagnostic group and diagnostic awareness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients who were unaware of their diagnosis at baseline showed average decreases in both satisfaction with daily life (QOL\u2010AD; paired mean difference (PMD)\u00a0=\u00a0\u22120.9, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) and physical functioning (SF\u201012 PCS; PMD\u00a0=\u00a0\u22122.5, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). In contrast, patients aware of their diagnosis at baseline showed no statistically discernable changes in most QOL domains (all <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). Of patients aware of their diagnosis at baseline (<jats:italic>n<\/jats:italic>\u00a0=\u00a0111), those who were still aware (<jats:italic>n<\/jats:italic>\u00a0=\u00a084) showed a decrease in mental functioning at follow up (<jats:italic>n<\/jats:italic>\u00a0=\u00a027; SF\u201012 MCS). Change in MoCA scores in patients unaware of their diagnosis was similar to that in patients aware of their diagnosis, \u22121.4 points (95% CI \u22122.6 to \u22120.6) and \u22121.7 points (95% CI \u22122.4 to \u22121.1) respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Implications<\/jats:title><jats:p>Awareness of one's diagnosis of MCI or AD, not the severity of cognitive impairment, may predict changes in patients' mental functioning, expectations of their memory, satisfaction with daily life, and physical functioning. The findings may help clinicians anticipate the types of threats to wellbeing that a patient might encounter and identify key domains for monitoring.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.5939","type":"journal-article","created":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T06:25:05Z","timestamp":1686378305000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Awareness of diagnosis predicts changes in quality of life in individuals with mild cognitive impairment and mild stage dementia"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3994-4343","authenticated-orcid":false,"given":"Shana D.","family":"Stites","sequence":"first","affiliation":[{"name":"Department of Psychiatry Perlman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Rubright","sequence":"additional","affiliation":[{"name":"National Board of Medical Examiners  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Harkins","sequence":"additional","affiliation":[{"name":"Penn Memory Center Department of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Karlawish","sequence":"additional","affiliation":[{"name":"Penn Memory Center Departments of Medicine, Medical Ethics and Health Policy, and Neurology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.241"},{"issue":"3","key":"e_1_2_9_3_1","first-page":"56","article-title":"Quality\u2010of\u2010life assessment in dementia drug development. 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