{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:43:59Z","timestamp":1786977839140,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AG008051"],"award-info":[{"award-number":["P30 AG008051"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AG066512"],"award-info":[{"award-number":["P30 AG066512"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention\/NIOSH","doi-asserted-by":"publisher","award":["U01 OH012486"],"award-info":[{"award-number":["U01 OH012486"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Subjective cognitive decline (SCD) is a preclinical stage of AD. White matter hyperintensities (WMH), an MRI marker of cerebral small vessel disease, associate with AD biomarkers and progression. The impact of WMH on SCD phenotype is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\/Design<\/jats:title>\n                    <jats:p>\n                      A retrospective, cross\u2010sectional analysis was conducted on a diverse cohort with SCD evaluated at the NYU Alzheimer's Disease Research Center between January 2017 and November 2021 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0234). The cohort was dichotomized into none\u2010to\u2010mild (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0202) and moderate\u2010to\u2010severe (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a032) WMH. Differences in SCD and neurocognitive assessments were evaluated via Wilcoxon or Fisher exact tests, with\n                      <jats:italic>p<\/jats:italic>\n                      \u2010values adjusted for demographics using multivariable logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Moderate\u2010to\u2010severe WMH participants reported more difficulty with decision making on the Cognitive Change Index (1.5 SD 0.7 vs. 1.2 SD 0.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0187) and worse short\u2010term memory (2.2 SD 0.4 vs. 1.9 SD 0.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0049) and higher SCD burden (9.5 SD 1.6 vs. 8.7 SD 1.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0411) on the Brief Cognitive Rating Scale. Moderate\u2010to\u2010severe WMH participants scored lower on the Mini\u2010Mental State Examination (28.0 SD 1.6 vs. 28.5 SD 1.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0491), and on delayed paragraph (7.2 SD 2.0 vs. 8.8 SD 2.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0222) and designs recall (4.5 SD 2.3 vs. 6.1 SD 2.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0373) of the Guild Memory Test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In SCD, WMH impact overall symptom severity, specifically in executive and memory domains, as well as objective performance on global and domain\u2010specific tests in verbal memory and visual working\/associative memory.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/gps.5948","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:10:45Z","timestamp":1686269445000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of white matter hyperintensities on subjective cognitive decline phenotype in a diverse cohort of cognitively normal older adults"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8480-8220","authenticated-orcid":false,"given":"Aaron","family":"Rothstein","sequence":"first","affiliation":[{"name":"Department of Neurology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Population Health NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony Q.","family":"Briggs","sequence":"additional","affiliation":[{"name":"Center for Cognitive Neurology Department of Neurology NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Bernard","sequence":"additional","affiliation":[{"name":"Center for Cognitive Neurology Department of Neurology NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhao","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Population Health NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Favilla","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Sloane","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Witsch","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun V.","family":"Masurkar","sequence":"additional","affiliation":[{"name":"Center for Cognitive Neurology Department of Neurology NYU Grossman School of Medicine  New York New York USA"},{"name":"Neuroscience Institute NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.02.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.10"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000000505"},{"key":"e_1_2_8_5_1","first-page":"288","article-title":"The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta\u2010analysis","author":"Debette S","year":"2010","journal-title":"BMJ Br Med J Publ Group"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002352"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010017\u20101717\u20107"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24647"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.139.9.1136"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2009.10.002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180341"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2019.08.004"},{"key":"e_1_2_8_14_1","first-page":"11","article-title":"Prevalence of abnormal Alzheimer\u2019s disease biomarkers in patients with subjective cognitive decline: cross\u2010sectional comparison of three European memory clinic samples Jose Luis Molinuevo (jlmolinuevo@barcelonabeta.org); Frank Jessen (frank.jessen@uk\u2010koeln.de); Wiesje Van der Flier (WM.vdFlier@vumc.nl)","author":"Wolfsgruber S","year":"2019","journal-title":"Alzheimer\u2019s Res Ther"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180285"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.009475"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2466\/pr0.1980.47.3f.1315"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.8.1274"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000149625.99732.69"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000358117"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.802501"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00669-4"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2022.103131"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17740501"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201186"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210695"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.7512"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e3181b208ef"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30431-4"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2021.19.2.181"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000507078"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbz120"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00877-6"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000411"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617708080995"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.735689"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2017.08.024"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2010.11.019"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.08.036"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000524499"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53209.x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071354"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.789054"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.06.023"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.5948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T01:23:40Z","timestamp":1692494620000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.5948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/gps.5948"],"URL":"https:\/\/doi.org\/10.1002\/gps.5948","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"2022-12-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e5948"}}