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Similarities and differences in the NPSs between preclinical\/prodromal Alzheimer's disease (AD) and prodromal Parkinson's disease dementia (PDD)\/Dementia with Lewy bodies (DLB) may exist. This study aimed to compare the NPSs between preclinical\/prodromal AD and prodromal PDD\/DLB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and three participants without dementia aged \u226550\u00a0years were included in this study. The mild behavioral impairment (MBI) total score and the MBI scores for each domain were calculated using the neuropsychiatric inventory questionnaire score. Participants were divided into five groups based on the clinical diagnosis by neurologists or psychiatrists in each institution based on the results of the amyloid positron emission tomography and dopamine transporter single photon emission computed tomography (DAT\u2010SPECT): Group 1: amyloid\u2010positive and abnormal DAT\u2010SPECT, Group 2: amyloid\u2010negative and abnormal DAT\u2010SPECT, Group 3: amyloid\u2010positive and normal DAT\u2010SPECT, Group 4: mild cognitive impairment unlikely due to AD with normal DAT\u2010SPECT, and Group 5: cognitively normal with amyloid\u2010negative and normal DAT\u2010SPECT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MBI abnormal perception or thought content scores were significantly higher in Group 1 than Group 5 (Bonferroni\u2010corrected <jats:italic>p<\/jats:italic>\u00a0=\u00a00.012). The MBI total score (Bonferroni\u2010corrected <jats:italic>p<\/jats:italic>\u00a0=\u00a00.011) and MBI impulse dyscontrol score (Bonferroni\u2010corrected <jats:italic>p<\/jats:italic>\u00a0=\u00a00.033) in Group 4 were significantly higher than those in Group 5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of both amyloid and putative Lewy body pathologies may be associated with psychotic symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.5993","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T08:46:11Z","timestamp":1693557971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Contribution of amyloid and putative Lewy body pathologies in neuropsychiatric 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