{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T12:40:24Z","timestamp":1766407224721,"version":"3.41.2"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014387","name":"ACADIA Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014387","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Real\u2010world evidence examining the incremental health care resource use (HCRU) and cost burden of incident dementia among patients with Parkinson's disease psychosis (PDP) are needed within the United States (US).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare HCRU and cost burden between PDP patients with incident dementia (PDP\u00a0+\u00a0D) versus without incident dementia (PDP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of inpatient (Part A), outpatient (Part B), and prescription drug (Part D) claims from the 100% Medicare sample was conducted to compare PDP\u00a0+\u00a0D patients versus PDP patients between 01\/01\/14\u201012\/31\/18. Patients with a diagnosis of dementia, psychosis, secondary parkinsonism, or other psychotic disorders, during 12\u2010month pre\u2010index were excluded. Patients in both groups were matched using 1:1 propensity score matching (PSM) methodology using 31 variables (age, sex, race, region and 27 Elixhauser comorbidity characteristics). Differences in 12\u2010month post\u2010index HCRU rates and mean per patient per year (PPPY) costs for all\u2010cause inpatient (IP) hospitalizations, and by type of IP stay (i.e., short\u2010term [ST\u2010stay], skilled nursing facility [SNF\u2010stay] and long\u2010term [LT\u2010stay]) were analyzed via logistic and gamma log\u2010link regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 12,484 patients who met our study criteria, 1855 PSM\u2010matched cohorts were identified. Mean age, gender, and comorbidities were similar in PSM groups. Approximately, 50.3% with PDP\u00a0+\u00a0D reported \u22651 all\u2010cause IP hospitalizations versus 36.0% with PDP (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) during 12\u2010month follow\u2010up. Specifically, all\u2010cause ST\u2010stay, SNF\u2010stay, and LT\u2010stay among PDP\u00a0+\u00a0D versus PDP patients were: 45.2% versus 35.7%, 28.3% versus 15.7%, and 8.5% versus 6.0% (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), respectively. Psychiatric\u2010related ST\u2010stay, SNF\u2010stay, and LT\u2010stay among PDP\u00a0+\u00a0D versus PDP patients were: 12.3% versus 9.0%, 7.5% versus 3.4%, and 2.4% versus 1.2% (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), respectively. Mean PPPY all\u2010cause IP hospitalization costs for PDP\u00a0+\u00a0D patients versus PDP patients was $17,891 (\u00b129,882) versus $11,599 (\u00b1$25,247) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with PDP\u00a0+\u00a0D experience significantly higher all\u2010cause and psychiatric\u2010related IP hospitalizations, including ST\u2010stays, LT stays, and SNF stays. They also had 54% greater mean PPPY IP hospitalization costs versus PDP patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.6017","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T06:28:56Z","timestamp":1699424936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Incremental health care resource utilization and costs associated among patients with Parkinson's disease psychosis and incident dementia: An analysis of medicare beneficiaries"],"prefix":"10.1002","volume":"38","author":[{"given":"Krithika","family":"Rajagopalan","sequence":"first","affiliation":[{"name":"Anlitiks Inc.  Orlando Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazia","family":"Rashid","sequence":"additional","affiliation":[{"name":"Acadia Pharmaceuticals  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daksha","family":"Gopal","sequence":"additional","affiliation":[{"name":"Anlitiks Inc.  Orlando Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilesh","family":"Doshi","sequence":"additional","affiliation":[{"name":"Acadia Pharmaceuticals  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_2_1","DOI":"10.1016\/j.parkreldis.2019.10.018"},{"doi-asserted-by":"publisher","key":"e_1_2_9_3_1","DOI":"10.1002\/mds.23664"},{"doi-asserted-by":"publisher","key":"e_1_2_9_4_1","DOI":"10.1016\/j.jns.2009.08.014"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.1007\/s11940\u2010013\u20100281\u20102"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.1136\/jnnp\u20102016\u2010314832"},{"doi-asserted-by":"publisher","key":"e_1_2_9_7_1","DOI":"10.1111\/j.1532\u20105415.2000.tb06891.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_8_1","DOI":"10.1177\/08919887211018280"},{"issue":"5","key":"e_1_2_9_9_1","first-page":"S83","article-title":"Parkinson's disease and Parkinson's disease psychosis: a perspective on the challenges, treatments, and economic burden","volume":"23","author":"Fredericks D","year":"2017","journal-title":"Am J Manag Care"},{"volume-title":"Strengths and Limitations of CMS Administrative Data in Research","year":"2018","key":"e_1_2_9_10_1"},{"unstructured":"What Are Long\u2010Term Care Hospitals? 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