{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:07:57Z","timestamp":1767136077599,"version":"build-2238731810"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T00:00:00Z","timestamp":1703289600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Apathy is a frequent neuropsychiatric syndrome after stroke. We determined whether pre\u2010morbid and early post\u2010stroke apathy predicts dementia 3\u00a0months after stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included ischemic stroke patients without dementia who participated in the Prospective Observational Polish Study on post\u2010stroke delirium. We used the Neuropsychiatric Inventory and clinician\u2010reported version of Apathy Evaluation Scale to score apathy symptoms before stroke and on day 8 after stroke. Patients underwent neuropsychological examination 3\u00a0months after stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 422 patients with ischemic stroke and without pre\u2010stroke dementia, 194 patients (mean age: 67.5\u00a0\u00b1\u00a012.3; 45.9% female) underwent neuropsychological examination. Dementia was diagnosed in 21.6% of them. Patients with dementia had higher apathy scores before stroke (mean: 0.9\u00a0\u00b1\u00a01.7 vs. 0.2\u00a0\u00b1\u00a00.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01) and on day 8 (mean: 37.2\u00a0\u00b1\u00a09.3 vs. 29.0\u00a0\u00b1\u00a09.6,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). Depressive symptoms did not differ between groups. In multivariate analysis adjusted for age, diabetes mellitus, stroke severity and in\u2010hospital delirium, apathy symptoms before stroke and on day 8 after stroke predicted post\u2010stroke dementia (adjusted OR: 1.59, 95%CI: 1.13\u20132.26,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01 and OR: 1.06, 95%CI: 1.01\u20131.11,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pre\u2010stroke and early post\u2010stroke apathy independently from age, stroke severity and delirium predicted dementia 3\u00a0months after stroke. Apathy might be useful in identifying at\u2010risk patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/gps.6043","type":"journal-article","created":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T10:17:26Z","timestamp":1703326646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pre\u2010stroke and early post\u2010stroke apathy is associated with increased risk of dementia 3\u00a0months after stroke"],"prefix":"10.1002","volume":"38","author":[{"given":"Anna Maria","family":"Lopatkiewicz","sequence":"first","affiliation":[{"name":"Department of Neurology Jagiellonian University Medical College  Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Slowik","sequence":"additional","affiliation":[{"name":"Department of Neurology Jagiellonian University Medical College  Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4086-0729","authenticated-orcid":false,"given":"Tomasz","family":"Dziedzic","sequence":"additional","affiliation":[{"name":"Department of Neurology Jagiellonian University Medical College  Krakow 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