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Biomarkers from CSF and plasma samples collected prior to surgery, including amyloid beta (A\u03b2)<jats:sub>42<\/jats:sub>, A\u03b2<jats:sub>40<\/jats:sub>, total (t)\u2010Tau, phosphorylated (p)\u2010Tau<jats:sup>181<\/jats:sup>, neurofilament\u2010light (NfL), and glial fibrillary acid protein (GFAP) were measured in cerebrospinal fluid (CSF) and plasma using sandwich enzyme\u2010linked immunosorbent assays (ELISAs) or ultrasensitive single molecule array (Simoa) immunoassays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Plasma GFAP correlated significantly with CSF GFAP and both plasma and CSF GFAP values were nearly two\u2010fold higher in delirium cases. The median paired difference between delirium case and control without delirium for plasma GFAP was not significant (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.074) but higher levels were associated with a greater risk for delirium (odds ratio 1.52, 95% confidence interval 0.85, 2.72 per standard deviation increase in plasma GFAP concentration) in this small study. No matched pair differences or associations with delirium were observed for NfL, p\u2010Tau 181, A\u03b2<jats:sub>40<\/jats:sub> and A\u03b2<jats:sub>42<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These preliminary findings suggest that plasma GFAP, a marker of astroglial activation, may be worth further investigation as a predictive risk marker for delirium.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.6044","type":"journal-article","created":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T07:54:05Z","timestamp":1704095645000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Biomarkers of neurodegeneration and neural injury as potential predictors for delirium"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8355-7047","authenticated-orcid":false,"given":"Tamara G.","family":"Fong","sequence":"first","affiliation":[{"name":"Department of Neurology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"},{"name":"Aging Brain Center Marcus Institute for Aging Research  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarinnapha M.","family":"Vasunilashorn","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Division of General Medicine Department of Medicine Beth Israel Deaconess Medical Center  Boston Massachusetts USA"},{"name":"Department of Epidemiology Harvard T.H. 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