{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:55:14Z","timestamp":1787237714502,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013893","name":"International Society for Bipolar Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012729","name":"Clinical and Translational Science Collaborative of Cleveland, School of Medicine, Case Western Reserve University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012729","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The Global Aging &amp; Geriatric Experiments in Bipolar Disorder Database (GAGE\u2010BD) project pools archival datasets on older age bipolar disorder (OABD). An initial Wave 1 (W1;\n                      <jats:italic>n<\/jats:italic>\n                      = 1369) analysis found both manic and depressive symptoms reduced among older patients. To replicate this finding, we gathered an independent Wave 2 (W2;\n                      <jats:italic>n<\/jats:italic>\n                      = 1232, mean \u00b1 standard deviation age 47.2 \u00b1 13.5, 65% women, 49% aged over 50) dataset.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design\/Methods<\/jats:title>\n                    <jats:p>Using mixed models with random effects for cohort, we examined associations between BD symptoms, somatic burden and age and the contribution of these to functioning in W2 and the combined W1 + W2 sample (n = 2601).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to W1, the W2 sample was younger (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), less educated (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), more symptomatic (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), lower functioning (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and had fewer somatic conditions (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). In the full W2, older individuals had reduced manic symptom severity, but age was not associated with depression severity. Age was not associated with functioning in W2. More severe BD symptoms (mania\n                      <jats:italic>p<\/jats:italic>\n                      \u2264 0.001, depression\n                      <jats:italic>p<\/jats:italic>\n                      \u2264 0.001) were associated with worse functioning. Older age was significantly associated with higher somatic burden in the W2 and the W1 + W2 samples, but this burden was not associated with poorer functioning.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a large, independent sample, older age was associated with less severe mania and more somatic burden (consistent with previous findings), but there was no association of depression with age (different from previous findings). Similar to previous findings, worse BD symptom severity was associated with worse functioning, emphasizing the need for symptom relief in OABD to promote better functioning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/gps.6057","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T08:54:40Z","timestamp":1711011280000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Bipolar symptoms, somatic burden and functioning in older\u2010age bipolar disorder: A replication study from the global aging &amp; geriatric experiments in bipolar disorder database (GAGE\u2010BD) project"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3073-668X","authenticated-orcid":false,"given":"Martha","family":"Sajatovic","sequence":"first","affiliation":[{"name":"Case Western Reserve University School of Medicine University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3908-9124","authenticated-orcid":false,"given":"Soham","family":"Rej","sequence":"additional","affiliation":[{"name":"Jewish General Hospital\/Lady Davis Hospital McGill University  Montreal Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8689-6199","authenticated-orcid":false,"given":"Osvaldo P.","family":"Almeida","sequence":"additional","affiliation":[{"name":"University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kursat","family":"Altinbas","sequence":"additional","affiliation":[{"name":"Sel\u00e7uk University Medical Faculty Department of Psychiatry Mazhar Osman Mood Clinic  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicent","family":"Balanz\u00e1\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Teaching Unit of Psychiatry and Psychological Medicine Department of Medicine University of Valencia CIBERSAM  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela G.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Mental Health Department Medicine School Minas Gerais University  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra J. M.","family":"Beunders","sequence":"additional","affiliation":[{"name":"GGZ inGeest Amsterdam UMC Vrije Universiteit Amsterdam Psychiatry, Amsterdam Public Health Research Institute  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary P.","family":"Blumberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farren B. 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