{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T17:08:40Z","timestamp":1743786520156},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,4,11]],"date-time":"2002-04-11T00:00:00Z","timestamp":1018483200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Health Scientific Board ETT, Hungary","award":["01917\/2000"],"award-info":[{"award-number":["01917\/2000"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cutaneous active vasodilatation is a cholinergic nerve mediated function of the sympathetic nervous system and the disturbed function of cholinergic neurotransmission is known as a prominent feature of Alzheimer's disease (AD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To assess this relationship, skin blood flow (SkBF) and other haemodynamic parameters were determined by a simple vasodilatory test, isometric handgrip exercise (IHG), in 22 late\u2010onset sporadic type AD and 20 aged control persons (AC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly higher cutaneous vascular resistance and decreased SkBF were found after the stimulus in the AD group. A smaller reduction (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.03) of R wave intervals on the electrocardiogram was observed in the AD group compared to the AC one. After IHG, change in systolic blood pressure was less in the AD (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) than in the AC group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that autonomic dysfunction affecting active vasodilator sympathetic, as well as parasympathetic functions is present in AD. 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