{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T20:45:03Z","timestamp":1764103503062,"version":"3.41.2"},"reference-count":72,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Neurological conditions such as Alzheimer's disease and stroke represent a substantial health burden to the world's ageing population. Cerebrovascular dysfunction is a key contributor to these conditions, affecting an individual's risk profile, age of onset, and severity of neurological disease. Recent data shows that early\u2010life events, such as maternal health during pregnancy, birth weight and exposure to environmental toxins can \u2018prime\u2019 the vascular system for later changes. With age, blood vessels can become less flexible and more prone to damage. This can lead to reduced blood flow to the brain, which is associated with cognitive decline and an increased risk of stroke and other cerebrovascular diseases. These in turn increase the risk of vascular dementia and Alzheimer's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aim to explore how early life factors influence cerebrovascular health, ageing and disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We have reviewed recently published literature from epidemiological studies, clinical cases and basic research which explore mechanisms that contribute to cerebrovascular and blood\u2010brain barrier dysfunction, with a particularly focus on those that assess contribution of early\u2010life events or vascular priming to subsequent injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Perinatal events have been linked to acute cerebrovascular dysfunction and long\u2010term structural reorganisation. Systemic disease throughout the lifetime that produce inflammatory or oxidative stress may further sensitise the cerebrovasculature to disease and contribute to neurodegeneration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>By identifying these early\u2010life determinants and understanding their mechanisms, scientists aim to develop strategies for preventing or mitigating cerebrovascular ageing\u2010related issues.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.6090","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T12:49:15Z","timestamp":1713358155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Developmental priming of early cerebrovascular ageing: Implications across a lifetime"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6019-5426","authenticated-orcid":false,"given":"Helen B.","family":"Stolp","sequence":"first","affiliation":[{"name":"Department of Comparative Biomedical Sciences Royal Veterinary College  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egle","family":"Solito","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Faculty of Medicine &amp; Dentistry Queen Mary University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.r116.760215"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.07.030"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2019.03.011"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12782"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108119"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016152244"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2008.04.003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678x17690761"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12888"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.09.017"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12221"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000001123"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201011172\u20101"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202101297r"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab331"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930211040720"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwac223"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/hjh.0000000000003209"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.120.033797"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12219"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014\u20103556"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2010.02.009"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.1.1"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.105019"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1203\/pdr.0b013e3182182366"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(00)02761\u20106"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wad.0000201854.62116.d7"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.09.020"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.42064"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000494368"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2021202423"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.249680"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13973"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20885"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441\u2010005\u20101088\u20106"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.3.435"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102990.2006.00773.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010022\u201000906\u2010w"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010021\u201000043\u20105"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhaa336"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201031149\u20103"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1113\/jp274938"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.255"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2006.05275.x"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.10.022"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010018\u20101344\u20109"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678x211032737"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2015.01.004"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010020\u201001810\u20108"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu501oa"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750\u20103639.2002.tb00430.x"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.06.007"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010018\u20100609\u20102"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13403"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.0406\u201009.2009"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109440(10)62365\u20106"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2005.04447.x"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678x17691292"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010014\u20100178\u20103"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2005.04483.x"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/469046"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.121018"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(20)30221\u20100"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2022.04.004"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2215\u20100366(21)00084\u20105"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010022\u201001689\u20103"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n693"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac372"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2022.10.003"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883\u2010020\u201002005\u20107"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.2015.1049997"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.6090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T03:03:14Z","timestamp":1714100594000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.6090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":72,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/gps.6090"],"URL":"https:\/\/doi.org\/10.1002\/gps.6090","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"type":"print","value":"0885-6230"},{"type":"electronic","value":"1099-1166"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2023-11-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e6090"}}