{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:07:20Z","timestamp":1778929640002,"version":"3.51.4"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Executive function deficits (EFD) in late\u2010life depression (LLD) has been reported to be associated with antidepressant treatment resistance, increased disability, and poor quality of life. However, the underlying neutral mechanisms of EFD in patients with the first episode of LLD remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 27 patients with first\u2010episode, drug\u2010naive LLD and 27 non\u2010depressed controls (NC) were recruited for the present research. Participants underwent the Trail Making Test, the 17\u2010item Hamilton depression rating scale (HAMD\u201017) test, and task\u2010state functional magnetic resonance imaging scans under the neutral Stroop task. LLD patients' executive functions, depressive symptoms, and brain activity were examined again after 6\u00a0months of antidepressant treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 27 LLD patients, 16 cases completed 6\u2010month follow\u2010ups. Patients in the LLD baseline group spent more time on the Trail Making Test A test than those in the NC group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). In the presence of an incongruency between the word color and meaning, the accuracy rate of the neutral Stroop task in the LLD baseline group was lower, and the reaction time was greater than that in the NC group, with statistically significant difference (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The HAMD\u201017 score in the LLD follow\u2010up group was significantly lower than that in the LLD baseline group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). More activated brain regions were present in the LLD baseline group than in the NC group when performing the neutral Stroop task. Compared with the LLD baseline group, abnormal activation of relevant brains in the cingulate\u2010prefrontal\u2010parietal network of LLD patients still existed in the LLD follow\u2010up group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LLD patients engaged more brain areas than the NC group while performing the neutral Stroop task. Abnormal activation of the cingulate\u2010prefrontal\u2010parietal network could be a contributing factor to EFD in LLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration<\/jats:title><jats:p>ChiCTR, ChiCTR2100042370 (Date of registration: 21\/01\/2021).<\/jats:p><\/jats:sec><jats:sec><jats:title>Limits<\/jats:title><jats:p>We didn't enroll enough first\u2010episode, LLD patients, the robustness of the findings need to be confirmed by large sample clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.6095","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T12:59:38Z","timestamp":1714481978000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Executive function deficits in patients with the first episode of late\u2010life depression before and after SSRI treatment: A pilot fMRI study"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2461-4723","authenticated-orcid":false,"given":"Chaomeng","family":"Liu","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders &amp; National Center for Mental Disorders Beijing Anding Hospital Capital Medical University  Beijing China"},{"name":"Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders &amp; National Center for Mental Disorders Beijing Anding Hospital Capital Medical University  Beijing China"},{"name":"Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weigang","family":"Pan","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders &amp; National Center for Mental Disorders Beijing Anding Hospital Capital Medical University  Beijing China"},{"name":"Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peixian","family":"Mao","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders &amp; National Center for Mental Disorders Beijing Anding Hospital Capital Medical University  Beijing China"},{"name":"Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Ren","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders &amp; National Center for Mental Disorders Beijing Anding Hospital Capital Medical University  Beijing China"},{"name":"Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[{"name":"Hebei Provincial Mental Health Center  Baoding China"},{"name":"Hebei Key Laboratory of Major Mental and Behavioral Disorders  Baoding China"},{"name":"The Sixth Clinical Medical College of Hebei University  Baoding China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Ma","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders &amp; National Center for Mental Disorders Beijing Anding Hospital Capital Medical University  Beijing China"},{"name":"Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102398"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.06.011"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.17399.1"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5851"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/cogp.1999.0734"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/s1355617798466037"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/s1355617798002653"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acn.2006.05.011"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2743"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010019\u20100514\u20106"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2012.12.009"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019442\u2010200201000\u201000012"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102314\u20109"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4246"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.08.014"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.05.025"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.894646"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.1713\u201020.2021"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.JGP.0b013e31802ea919"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.04.023"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40501\u2010020\u201000216\u2010w"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214998"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyac049"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.05.048"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1037\/\/0894\u20104105.16.3.335"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.6.552"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2017.00557"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.916041"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2012.00116"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073191115602552"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acv089"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.12740\/PP\/OnlineFirst\/63765"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.3276"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1107320"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2011.10.006"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13350"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1037\/\/0096\u20103445.131.2.220"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033\u20102909.109.2.163"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.13.7654"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065\u2010018\u20109369\u20105"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.08.041"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2020.0742"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3857"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.14m09344"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010020\u201001036\u20105"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0006\u20103223(99)00056\u20106"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858413514136"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/b978\u20100\u2010444\u201063622\u20105.00001\u20102"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1243894"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2020.03.001"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/yic.0000000000000023"},{"issue":"13","key":"e_1_2_12_53_1","first-page":"5","article-title":"Interactions of antidepressants with neurotransmitter transporters and receptors and their clinical relevance","volume":"64","author":"Richelson E","year":"2003","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.4065\/76.5.511"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.06.013"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.6095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T04:04:46Z","timestamp":1716782686000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.6095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,30]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/gps.6095"],"URL":"https:\/\/doi.org\/10.1002\/gps.6095","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,30]]},"assertion":[{"value":"2023-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e6095"}}