{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:33:25Z","timestamp":1780490005777,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the differences in patient\/caregiver characteristics, their treatment needs, and the attending physician's understanding of those treatment needs according to the duration after diagnosis of dementia with Lewy bodies (DLB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a post hoc analysis of a multicenter, cross\u2010sectional, questionnaire survey study. A total of 263 patient\u2013caregiver pairs were reclassified into two groups according to the median duration after diagnosis of DLB as follows: short (&lt;24\u00a0months; S\u2010group) and long (\u226524\u00a0months; L\u2010group) post\u2010DLB diagnosis duration. Treatment need was defined as the symptom domain that caused the patient or caregiver the most distress. Concordance rates between patient\u2013physician and caregiver\u2013physician were calculated for physicians' understanding of treatment needs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this analysis, 126 pairs (32 physicians) and 137 pairs (34 physicians) were classified as the S\u2010 and L\u2010groups, respectively. Patient and caregiver characteristics were broadly similar between groups (mean age for patients 78.7\u00a0\u00b1\u00a06.6 vs. 79.8\u00a0\u00b1\u00a06.7, for caregivers 64.7\u00a0\u00b1\u00a012.9 vs. 64.9\u00a0\u00b1\u00a012.8; number of male\/female for patients 61\/65 vs. 67\/70, for caregivers 34\/92 vs. 38\/99), but the prevalence of parkinsonism (82.5% vs. 66.7%) and autonomic dysfunction (49.6% vs. 33.3%), severity of parkinsonism (MDS\u2010UPDRS Part III total scores, 29.2\u00a0\u00b1\u00a022.6 vs. 18.0\u00a0\u00b1\u00a016.4; Part II total score, 14.6\u00a0\u00b1\u00a012.0 vs. 7.6\u00a0\u00b1\u00a07.9), and caregiver burden (J\u2010ZBI_8 score, 9.1\u00a0\u00b1\u00a06.7 vs. 7.5\u00a0\u00b1\u00a05.8) were higher in the L\u2010group than the S\u2010group. Regarding treatment needs, the invalid answer rates for patients were 34.9% and 46.8%, and those for caregivers were 28.6% and 34.9% in the S\u2010 and L groups, respectively. Patients' treatment needs did not significantly differ (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.056), but S\u2010group patients were more likely to select cognitive impairment (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.045) as their treatment need, whereas L\u2010group patients were more likely to select parkinsonism (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003). Caregivers' treatment needs significantly differed (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.032) between groups. S\u2010group caregivers were more likely to select cognitive impairment (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), whereas L\u2010group caregivers were more likely to select other symptom domains such as parkinsonism (S\u2010group vs. L\u2010group: 10.3% vs. 16.7%), psychiatric symptoms (20.6% vs. 24.6%), sleep\u2010related disorder (4.0% vs. 7.1%), and autonomic dysfunction (4.8% vs. 9.5%). Concordance rates between patient\u2013physician and caregiver\u2013physician were low in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There were some differences in characteristics according to the duration after diagnosis of DLB. Cognitive dysfunction may be a particular concern for patients and caregivers soon after diagnosis of DLB. Treatment needs of patients and caregivers for parkinsonism, psychiatric symptoms, sleep\u2010related disorder, or autonomic dysfunction were different according to the duration after diagnosis of DLB. Physicians' perception of patients'\/caregivers' treatment needs was poor regardless of the duration after diagnosis of DLB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical trial registration<\/jats:title><jats:p>UMIN Clinical Trials Registry (UMIN000041844).<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.6122","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T03:10:08Z","timestamp":1722481808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Post hoc analysis of the characteristics and treatment needs of patients with dementia with Lewy bodies (DLB) and their caregivers and their physicians' awareness of those treatment needs according to the duration after diagnosis of DLB"],"prefix":"10.1002","volume":"39","author":[{"given":"Manabu","family":"Ikeda","sequence":"first","affiliation":[{"name":"Department of Psychiatry Osaka University Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunji","family":"Toya","sequence":"additional","affiliation":[{"name":"Medical Science Sumitomo Pharma Co., Ltd.  Chuo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Manabe","sequence":"additional","affiliation":[{"name":"Department of Advanced Clinical Medicine Division of Dementia and Geriatric Medicine Kanagawa Dental University School of Dentistry  Yokosuka Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Yamakage","sequence":"additional","affiliation":[{"name":"Insight Clinical Development Group 3H Medi Solution Inc.  Toshima\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Osaka University Graduate School of Medicine  Suita Osaka Japan"},{"name":"Department of Neuropsychiatry Kindai University Faculty of Medicine  Osakasayama Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713000494"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010018\u20100350\u20106"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afi190"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12005"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.01.005"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2021.111248"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12905"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988716656083"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120\u2010022\u201000417\u2010w"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010022\u201001130\u20104"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20103956(75)90026\u20106"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22340"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.48.5_suppl_6.10s"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.11477\/mf.1416101719"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/20.6.649"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5839"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(03)00619\u20107"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.56.9.1143"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2003.10028"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010161109"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102015\u2010010357"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012450"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e3181c72b5d"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcgg.2012.04.008"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12740"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13745"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1709"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326238"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010201326"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.6122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T04:16:14Z","timestamp":1725077774000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.6122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,31]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/gps.6122"],"URL":"https:\/\/doi.org\/10.1002\/gps.6122","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,31]]},"assertion":[{"value":"2024-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e6122"}}