{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:52:24Z","timestamp":1792133544008,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012295","name":"NIHR Newcastle Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012295","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/W000229\/1"],"award-info":[{"award-number":["MR\/W000229\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002283","name":"Alzheimer\u2019s Research UK","doi-asserted-by":"publisher","award":["ARUK\u2010PG2015\u201013"],"award-info":[{"award-number":["ARUK\u2010PG2015\u201013"]}],"id":[{"id":"10.13039\/501100002283","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Predicting which individuals may convert to dementia from mild cognitive impairment (MCI) remains difficult in clinical practice. Electroencephalography (EEG) is a widely available investigation but there is limited research exploring EEG connectivity differences in patients with MCI who convert to dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Participants with a diagnosis of MCI due to Alzheimer's disease (MCI\u2010AD) or Lewy body disease (MCI\u2010LB) underwent resting state EEG recording. They were followed up annually with a review of the clinical diagnosis (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a066). Participants with a diagnosis of dementia at year 1 or year 2 follow up were classed as converters (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a023) and those with a diagnosis of MCI at year 2 were classed as stable (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a043). We used phase lag index (PLI) to estimate functional connectivity as well as analysing dominant frequency (DF) and relative band power. The Network\u2010based statistic (NBS) toolbox was used to assess differences in network topology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The converting group had reduced DF (\n                      <jats:italic>U<\/jats:italic>\n                      \u00a0=\u00a0285.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005) and increased relative pre\u2010alpha power (\n                      <jats:italic>U<\/jats:italic>\n                      \u00a0=\u00a0702,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005) consistent with previous findings. PLI showed reduced average beta band synchrony in the converting group (\n                      <jats:italic>U<\/jats:italic>\n                      \u00a0=\u00a0311,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.014) as well as significant differences in alpha and beta network topology. Logistic regression models using regional beta PLI values revealed that right central to right lateral (Sens\u00a0=\u00a056.5%, Spec\u00a0=\u00a086.0%, \u22122LL\u00a0=\u00a072.48,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.017) and left central to right lateral (Sens\u00a0=\u00a047.8%, Spec\u00a0=\u00a081.4%, \u22122LL\u00a0=\u00a071.37,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.012) had the best classification accuracy and fit when adjusted for age and MMSE score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with MCI who convert to dementia have significant differences in EEG frequency, average connectivity and network topology prior to the onset of dementia. The MCI group is clinically heterogeneous and have underlying physiological differences that may be driving the progression of cognitive symptoms. EEG connectivity could be useful to predict which patients with MCI\u2010AD and MCI\u2010LB convert to dementia, regardless of the neurodegenerative aetiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/gps.6138","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T22:09:41Z","timestamp":1726092581000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["EEG Functional Connectivity Differences Predict Future Conversion to Dementia in Mild Cognitive Impairment With Lewy Body or Alzheimer Disease"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0989-1175","authenticated-orcid":false,"given":"Jahfer","family":"Hasoon","sequence":"first","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9812-3150","authenticated-orcid":false,"given":"Calum A.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"},{"name":"Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen (DZNE) Rostock\u2010Greifswald  Rostock Germany"},{"name":"Department of Neurology University Medical Center Rostock  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Colloby","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C.","family":"Donaghy","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan J.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John\u2010Paul","family":"Taylor","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-316844"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190924"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00496"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30153-X"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-020-01576-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2741\/4587"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10090616"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00190"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2018.03.013"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.07.009"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009977"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102017\u2010316844"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-021-00709-y"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2018.07.012"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29248"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2017.03.007"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20346"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22984-5"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26309"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/ab234b"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1109\/EMBC.2018.8512270"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717003956"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010190924"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012060"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009323"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00650-1"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2003.10.009"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.03.013"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(85)90005-7"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.041"},{"key":"e_1_2_10_34_1","unstructured":"E. M.Gerber permutest. MATLAB Central File Exchange (2023)."},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00496"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010181081"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25289"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00058"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0197\u20104580(00)00153\u20106"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.680200"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138866"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010130842"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27997"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0033291720001130"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000436942.55281.47"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(19)30153\u2010x"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27867"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181105"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.6138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T02:57:23Z","timestamp":1727146643000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.6138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":47,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/gps.6138"],"URL":"https:\/\/doi.org\/10.1002\/gps.6138","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"2024-02-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e6138"}}