{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:12:17Z","timestamp":1783815137837,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,22]],"date-time":"2024-09-22T00:00:00Z","timestamp":1726963200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Pharmacological and non\u2010pharmacological interventions are mostly designed for patients with early Alzheimer's disease (AD) dementia. Long\u2010term case management and planning for the remainder of life with disability require an estimation of the survival duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cohort study utilized data from the National Health Insurance Research Database, Taiwan, to identify incident cases of mild\u2010to\u2010moderate AD dementia diagnosed from 2000 to 2002, followed through December 31, 2017. A multivariate Cox proportional hazards regression model was constructed to compare the independent effects of age, sex, and comorbidities on all\u2010cause mortality risk. Cumulative survival rates and survival times were estimated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 5258 incident cases were identified, all treated with cholinesterase inhibitors after diagnosis confirmation by an expert committee. During the 15\u2010year follow\u2010up period, 4331 deaths occurred. The 1\u2010, 3\u2010, 5\u2010, 10\u2010, and 15\u2010year cumulative survival rates were 95, 92, 67, 37, and 18, respectively. The median (95% CI) survival time after diagnosis was 7.69 (7.46\u20137.90) years overall, 6.37 (6.06\u20136.65) years in men, and 8.81 (8.49\u20139.12) years in women. After stratification by age and number of comorbidities, the median survival time ranged from 13.72 (ages 40\u201364) to 5.29 (ages \u2265 80) years among those without comorbidities. For those with \u2265 3 comorbidities, the median survival times decreased to 6.43 for individuals diagnosed at ages 40\u201364 and to 2.98\u00a0years for those diagnosed at age 80 or older.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This nationwide, large, long\u2010term cohort study provided survival rates and durations from diagnosis to death, varying by sex, age group, and presence\/number of comorbidities. This information can serve as a foundation for further cost\u2010effectiveness studies on new treatments, and may aid clinicians, patients, and families in shared decision\u2010making and advance personalized care planning for early dementia cases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.6152","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T01:30:16Z","timestamp":1727055016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Survival After the Diagnosis of Mild\u2010to\u2010Moderate Alzheimer's Disease Dementia: A 15\u2010Year National Cohort Study in Taiwan"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4656-7032","authenticated-orcid":false,"given":"Yu","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Neurology En Chu Kong Hospital  New Taipei City Taiwan"},{"name":"Department of Neurology National Taiwan University Hospital College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9644-3129","authenticated-orcid":false,"given":"Chih\u2010Ching","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Health Care Management National Taipei University of Nursing and Health Sciences  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0321-8908","authenticated-orcid":false,"given":"Chung\u2010Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Public Health College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"Department of Public Health College of Public Health China Medical University  Taichung Taiwan"},{"name":"Department of Healthcare Administration, College of Medical and Health Science Asia University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4158-4423","authenticated-orcid":false,"given":"Ming\u2010Jang","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Neurology National Taiwan University Hospital College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,22]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"Dementia","year":"2023"},{"key":"e_1_2_13_3_1","unstructured":"\u53f0\u7063\u5931\u667a\u75c7\u4eba\u53e3\u63a8\u4f30 Taiwan Alzheimer's Disease Association. 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