{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:53:11Z","timestamp":1753869191193,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association between suspected pseudobulbar affect (PBA), clinical diagnosis, cognitive testing, and self\u2010reported mood in older adults presenting for evaluation of dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Patients presenting to an outpatient memory disorders clinic (<jats:italic>N<\/jats:italic>\u00a0=\u00a0311).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used traditional and novel network modeling approaches to examine associations between neuropsychological (NP) tests, patient and clinician rating scales, and the Center for Neurological Study\u2010Lability Scale (CNS\u2010LS) among patients with suspected AD (<jats:italic>n<\/jats:italic>\u00a0=\u00a0133) and other neurocognitive diagnosis (<jats:italic>n<\/jats:italic>\u00a0=\u00a0178). We then examined differences in test performance between patients with and without suspected PBA (CNS\u2010LS cut\u2010off of \u2265 13), while accounting for demographic and psychiatric covariates with propensity score matching. Group differences were assessed with Bayesian models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prevalence of suspected PBA in AD was slightly less than half (44.4%) and at a similar rate in other dementias (e.g., 46.9% in CVD and 45.5% in LBD). In network models, the CNS\u2010LS was associated with higher anxiety and better word list recall. After accounting for covariates, AD patients with suspected PBA performed better on word list recall <jats:italic>\u03b2<\/jats:italic><jats:sub><jats:italic>M<\/jats:italic><\/jats:sub>\u00a0=\u00a00.40, 95% CI [0.15, 0.66], and committed fewer false positive errors on recognition <jats:italic>\u03b2<\/jats:italic><jats:sub><jats:italic>M<\/jats:italic><\/jats:sub>\u00a0=\u00a0\u22121.51, 95% CI [\u22122.34, \u22120.59] than AD patients without suspected PBA. There were no differences in patients with any other diagnostic impression, nor group differences on other NP measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with suspected PBA and AD diagnosis had better memory recall and recognition than those without suspected PBA, suggesting that impaired emotional regulation may be an early sign of AD in patients with less prominent memory decline. Better understanding PBA in neurodegenerative diseases, including prevalence and comorbidity with psychiatric conditions, could help with early identification, education, and initiation of treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.70002","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T03:44:30Z","timestamp":1729568670000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Suspected Pseudobulbar Affect in Neurodegenerative Disease"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2466-0367","authenticated-orcid":false,"given":"Maureen K.","family":"O\u2019Connor","sequence":"first","affiliation":[{"name":"Neuropsychology Service Bedford VA Healthcare System  Bedford Massachusetts USA"},{"name":"Geriatric Research Education and Clinical Center Bedford VA Healthcare System  Bedford Massachusetts USA"},{"name":"Department of Neurology Boston University School of Medicine  Boston Massachusetts USA"},{"name":"Alzheimer's Disease Research Center Department of Neurology Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University School of Medicine  Boston Massachusetts USA"},{"name":"Alzheimer's Disease Research Center Department of Neurology Boston University School of Medicine  Boston Massachusetts USA"},{"name":"Center for Translational Cognitive Neuroscience VA Boston Healthcare System  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9e","family":"DeCaro","sequence":"additional","affiliation":[{"name":"Center for Translational Cognitive Neuroscience VA Boston Healthcare System  Boston Massachusetts 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