{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T02:39:57Z","timestamp":1778726397813,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T00:00:00Z","timestamp":1731715200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009618","name":"Sundhed, Region Midtjylland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009618","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Psychotropic drug use is common in older adults, with off\u2010label use reported despite limited understanding of the safety outcomes compared to on\u2010label use. Incomplete recordings of treatment indications in the Danish National Prescription Register (DNPR) raise concerns about potential off\u2010label medication use, particularly among older adults. We, therefore, investigated the association between psychotropic prescriptions with non\u2010registered indications in DNPR and the 1\u2010year all\u2010cause mortality in older adults, including subgroups with any psychiatric disorders, depression, or dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Register\u2010based cohort study following all older adults (\u2265 65) who redeemed a first\u2010time (since 1995) prescription of either antidepressants, antipsychotics, or benzodiazepine during 2006\u20132017. Redemption of a prescription with non\u2010registered indications in the DNPR was the exposure. The outcome, 1\u2010year all\u2010cause mortality was analyzed using Poisson regression, estimating incidence rate ratios with 95% confidence intervals, adjusting for socio\u2010demographics and clinical factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>32% of prescriptions filled by 202,067 individuals for antidepressants, 37% of 97,387 for antipsychotics, and 22% of 130,471 for benzodiazepines had non\u2010registered indications. No significant differences in mortality rates were found for antidepressants and antipsychotics with non\u2010registered indications, while higher mortality rates were associated with benzodiazepines, mitigated when excluding individuals receiving intravenous administrations representing end\u2010of\u2010life treatment. The results remained consistent in subgroup analyses in patients with any psychiatric disorders, depression, or dementia and further stratified analyses by sex and age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found that while psychotropic prescriptions with non\u2010registered indications in DNPR were prevalent in older adults, they were not associated with excess mortality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.70014","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T14:44:08Z","timestamp":1731768248000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Psychotropic Prescriptions With Non\u2010Registered Indications and the Risk of Mortality in Older Adults: A Danish Nationwide Cohort Study"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3651-4612","authenticated-orcid":false,"given":"Kazi","family":"Ishtiak\u2010Ahmed","sequence":"first","affiliation":[{"name":"Department of Affective Disorders Aarhus University Hospital Psychiatry  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7946-6556","authenticated-orcid":false,"given":"Christina","family":"Jensen\u2010Dahm","sequence":"additional","affiliation":[{"name":"Department of Neurology Danish Dementia Research Centre Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0409-2702","authenticated-orcid":false,"given":"Kaj Sparle","family":"Christensen","sequence":"additional","affiliation":[{"name":"Research Unit for General Practice Aarhus University  Aarhus Denmark"},{"name":"Department of Public Health Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0293-220X","authenticated-orcid":false,"given":"Gunhild","family":"Waldemar","sequence":"additional","affiliation":[{"name":"Department of Neurology Danish Dementia Research Centre Rigshospitalet University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6194-1099","authenticated-orcid":false,"given":"Christiane","family":"Gasse","sequence":"additional","affiliation":[{"name":"Department of Affective Disorders Aarhus University Hospital Psychiatry  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266\u2010014\u20100205\u20101"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215\u20100366(21)00292\u20103"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266\u2010016\u20100380\u20103"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266\u2010023\u201001018\u20104"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmhi.2016.02.001"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5841"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2045796021000159"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j603"},{"issue":"3","key":"e_1_2_11_10_1","first-page":"e109","article-title":"Off\u2010Label Use of Antipsychotic Medications in Medicaid","volume":"18","author":"Leslie D. 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