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The reporting odds ratio and its corresponding 95% confidence intervals were calculated. The chi\u2010squared test was used to evaluate differences in categorical variables, and a two\u2010way ANOVA followed by a Bonferroni post\u2010test was used to compare the AEs reported for antidementia medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Memantine was associated with 544 selected cardiac and vascular disorder AEs. A signal for bradycardia, myocardial infarction, atrial fibrillation and cardiac arrest has been observed in patients receiving choline esterase inhibitors compared to those receiving memantine. On the other hand, cardiac failure and deep vein thrombosis AEs were found to be more common in patients receiving memantine. The majority of reported cardiac and vascular AEs were reported more frequently in female patients. More cases of cardiac failure, cardiac arrest, and deep vein thrombosis were reported in females than males taking memantine, but bradycardia was more common in males than females.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Healthcare professionals should be aware of the potential for cardiovascular AEs during treatment with antidementia medications and the possibility of sex differences in this regard. Memantine differs from cholinesterase inhibitors in terms of cardiovascular AEs, and there may be sex\u2010related differences in the proportion of these AEs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.70018","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T05:10:26Z","timestamp":1732079426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparative Post\u2010Marketing Surveillance of Memantine and Cholinesterase Inhibitors: Cardiovascular Adverse Events With a Focus on Sex Differences Using the FDA Adverse Event Reporting System Database"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7822-3154","authenticated-orcid":false,"given":"Zinnet \u015eevval","family":"Aksoyalp","sequence":"first","affiliation":[{"name":"Department of Pharmacology Faculty of Pharmacy Izmir Katip Celebi University  Izmir 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