{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:12:18Z","timestamp":1789848738094,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Assessing (self\u2010reported) quality of life (QoL) in patients with Korsakoff's syndrome (KS) is important to gain insight into these patients' well\u2010being and to optimize their care in long\u2010term care facilities. In this study, we describe the development of the QUALIKO\u2010Self Report (QUALIKO\u2010SR), an instrument for objectifying self\u2010reported QoL in patients with KS. Next, we compared the QUALIKO\u2010SR scores with the scores on the QUALIKO\u2010Proxy Version (QUALIKO\u2010PV) and examined changes in QoL over time. Finally, we assessed the convergent validity and investigated whether QUALIKO\u2010SR scores were related to the severity of the cognitive impairments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study took place in specialized long\u2010term care facilities providing care for patients with KS. 116 patients with alcoholic KS participated in this study. The QUALIKO\u2010SR was developed and validated against the QUALIKO\u2010PV, the Manchester Short Assessment of Quality of Life (MANSA\u201016), and the Montreal Cognitive Assessment 8.1 (MoCA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant differences were found between self\u2010 and proxy reported QoL on the subscales Negative Affect, Social Isolation, and Feeling at Home. No significant differences were found on the other subscales. QUALIKO\u2010SR scores did not significantly vary over time. However, caregivers reported significant improvements in Care Relationships, Autonomy, Restless Tense Behavior, Social Isolation, and Feeling at Home over time. A significant, positive association was found between the QUALIKO\u2010SR and the MANSA\u201016. No significant correlations were found between the QUALIKO\u2010SR and the MoCA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study describes the development and validation of a self\u2010report instrument for objectifying QoL in patients with KS living in 24\u2010h care facilities, the QUALIKO\u2010SR. Measuring QoL in patients with severe cognitive impairments, such as patients with KS, is complex and we advise to include both self\u2010report and proxy\u2010report measures in future studies as well as in clinical practice. The availability of the QUALIKO\u2010SR and QUALIKO\u2010PV encourages researchers and clinicians to do so in patients with KS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.70103","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T03:04:15Z","timestamp":1747883055000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Validity and Sensitivity to Change of a Self\u2010Report Quality of Life Measure in Patients With Korsakoff's Syndrome"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2155-629X","authenticated-orcid":false,"given":"Yvonne C. M.","family":"Rensen","sequence":"first","affiliation":[{"name":"Vincent van Gogh Institute for Psychiatry Centre of Excellence for Korsakoff and Alcohol\u2010Related Cognitive Disorders  Venray the Netherlands"},{"name":"Radboud University Donders Institute for Brain  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrie","family":"de Waal \u2010 Gordijn","sequence":"additional","affiliation":[{"name":"Salios Regional Expertise Centre Korsakoff Het Dijckhuis  Dordrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9500-9793","authenticated-orcid":false,"given":"Roy P. 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