{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T02:30:12Z","timestamp":1777170612097,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify the variables at baseline, including physical frailty, that might predict cognitive and functional deficits in a 9\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This investigation included participants from the FIBRA study in Campinas city and Ermelino Matarazzo, subdistrict of S\u00e3o Paulo city, with complete data collected at baseline and follow\u2010up for the variables sex, age, education, frailty phenotype, number of chronic diseases, and tobacco and alcohol use. Of the initial 1284 participants at baseline, 98 that exhibited cognitive impairment were excluded. At follow\u2010up, 451 participants were located and reinterviewed and 85 scored below the cut\u2010off on the Mini\u2010Mental State Exam (MMSE), of which 45 also presented functional deficit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The follow\u2010up subsample comprised predominantly participants that were female (68.1%), aged 65\u201374\u00a0years (71.6%), and had low education (0\u20134\u00a0years of education, 75.6%). At baseline, 35.5% were non\u2010frail, 57.0% pre\u2010frail and 7.5% frail, whereas at follow\u2010up, 29.4% were non\u2010frail, 62.3% pre\u2010frail and 8.3% frail. Logistic regression showed that age and education but not frailty at baseline were associated with cognitive and functional deficits at follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Higher age and lower education at baseline were predictors of cognitive and functional deficits after 9\u00a0years, whereas frailty was not. Further longitudinal studies should be conducted to elucidate the factors predicting cognitive and functional decline in low\u2010and middle\u2010income countries.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.70104","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T09:35:25Z","timestamp":1748597725000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Does Frailty Predict Cognitive and Functional Deficits After Nine Years?"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1026-3528","authenticated-orcid":false,"given":"Beatriz Raz Franco","family":"de Santana","sequence":"first","affiliation":[{"name":"Department of Gerontology Faculty of Medical Sciences Post Graduation Program in Gerontology Universidade Estadual de Campinas  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1813-996X","authenticated-orcid":false,"given":"Daniela","family":"de Assump\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Gerontology Faculty of Medical Sciences Post Graduation Program in Gerontology Universidade Estadual de Campinas  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7316-1145","authenticated-orcid":false,"given":"Fl\u00e1via Silva Arbex","family":"Borim","sequence":"additional","affiliation":[{"name":"Department of Gerontology Faculty of Medical Sciences Post Graduation Program in Gerontology Universidade Estadual de Campinas  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3806-7895","authenticated-orcid":false,"given":"Ivan","family":"Aprahamian","sequence":"additional","affiliation":[{"name":"Department of Gerontology Faculty of Medical Sciences Faculdade de Medicina de Jundia\u00ed Post Graduation Program in Gerontology  Jundiai Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5298-7714","authenticated-orcid":false,"given":"Ligiana Pires","family":"Corona","sequence":"additional","affiliation":[{"name":"Department of Gerontology Faculty of Medical Sciences Post Graduation Program in Gerontology Universidade Estadual de Campinas  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8587-8298","authenticated-orcid":false,"given":"Samila Sathler Tavares","family":"Batistoni","sequence":"additional","affiliation":[{"name":"Department of Gerontology School of Communications and Arts Post Graduation Program in Gerontology Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6839-4606","authenticated-orcid":false,"given":"Deusivania Vieira","family":"da Silva Falc\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Gerontology School of Communications and Arts Post Graduation Program in Gerontology Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5220-410X","authenticated-orcid":false,"given":"Meire","family":"Cachioni","sequence":"additional","affiliation":[{"name":"Department of Gerontology School of Communications and Arts Post Graduation Program in Gerontology Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9713-8617","authenticated-orcid":false,"given":"Ruth Caldeira","family":"de Melo","sequence":"additional","affiliation":[{"name":"Department of Gerontology School of Communications and Arts Post Graduation Program in Gerontology Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6833-7668","authenticated-orcid":false,"given":"Anita Liberalesso","family":"Neri","sequence":"additional","affiliation":[{"name":"Department of Gerontology Faculty of Medical Sciences Post Graduation Program in Gerontology Universidade Estadual de Campinas  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9182-2450","authenticated-orcid":false,"given":"Monica Sanches","family":"Yassuda","sequence":"additional","affiliation":[{"name":"Department of Gerontology Faculty of Medical Sciences Post Graduation Program in Gerontology Universidade Estadual de Campinas  Campinas Brazil"},{"name":"Department of Gerontology School of Communications and Arts Post Graduation Program in Gerontology Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization (WHO) [Internet]. \u201cGlobal Status Report on the Public Health Response to Dementia \u201d2019 https:\/\/www.who.int\/publications\/i\/item\/9789240033245."},{"key":"e_1_2_10_3_1","article-title":"World Alzheimer Report 2023: Reducing Dementia Risk: Never Too Early, Never Too Late","author":"Long S.","year":"2023","journal-title":"Alzheimer\u2019s Disease International"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(20)30367\u20106"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glad025"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101703"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regg.2018.12.007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988709332942"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/wad.0000000000000122"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002093\u2010200204000\u201000007"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12237"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440\u2010023\u201001271\u20105"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v14.i2.92"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100044\u20101779506"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k4922"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12820"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010020\u201000017\u2010z"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.2008.02136.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1166365"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102021\u2010327396"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0102\u2010311x2013000800015"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1590\/1981\u201022562022025.210224.pt"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20103956(75)90026\u20106"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0004\u2010282x2003000500014"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/37.3.323"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.m146"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201016104\u2010y"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010020\u201001539\u20102"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000520882"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2019.00026"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt013"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.057847"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874\u2010020\u201001203\u20108"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606\u2010021\u201007169\u20107"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12542"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(12)70191\u20106"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2022.10.015"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12542"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech\u20102017\u2010210116"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.70104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T07:54:18Z","timestamp":1752911658000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.70104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,30]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/gps.70104"],"URL":"https:\/\/doi.org\/10.1002\/gps.70104","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,30]]},"assertion":[{"value":"2024-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70104"}}