{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T10:58:25Z","timestamp":1775645905947,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T00:00:00Z","timestamp":1751155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T00:00:00Z","timestamp":1751155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002283","name":"Alzheimer\u2019s Research UK","doi-asserted-by":"publisher","award":["ARUK\u2010RF2021B\u2010007"],"award-info":[{"award-number":["ARUK\u2010RF2021B\u2010007"]}],"id":[{"id":"10.13039\/501100002283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002283","name":"Alzheimer\u2019s Research UK","doi-asserted-by":"publisher","award":["ARUK\u2010PPG2023B\u2010036"],"award-info":[{"award-number":["ARUK\u2010PPG2023B\u2010036"]}],"id":[{"id":"10.13039\/501100002283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002283","name":"Alzheimer\u2019s Research UK","doi-asserted-by":"publisher","award":["ARUK\u2010PPG2023B\u2010046"],"award-info":[{"award-number":["ARUK\u2010PPG2023B\u2010046"]}],"id":[{"id":"10.13039\/501100002283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00019\/1"],"award-info":[{"award-number":["MC_UU_00019\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00019\/3"],"award-info":[{"award-number":["MC_UU_00019\/3"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RO1AG017644"],"award-info":[{"award-number":["RO1AG017644"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R00AG071838"],"award-info":[{"award-number":["R00AG071838"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000269","name":"Economic and Social Research Council","doi-asserted-by":"publisher","award":["ES\/T012091\/1"],"award-info":[{"award-number":["ES\/T012091\/1"]}],"id":[{"id":"10.13039\/501100000269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000269","name":"Economic and Social Research Council","doi-asserted-by":"publisher","award":["ES\/S013830\/1"],"award-info":[{"award-number":["ES\/S013830\/1"]}],"id":[{"id":"10.13039\/501100000269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000320","name":"Alzheimer's Society","doi-asserted-by":"publisher","award":["477"],"award-info":[{"award-number":["477"]}],"id":[{"id":"10.13039\/501100000320","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2022\u201013723OB\u2010100"],"award-info":[{"award-number":["PID2022\u201013723OB\u2010100"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Previous research investigating associations between life satisfaction and risk of Alzheimer's disease (AD) has been mixed. This association may differ depending on genetic risk for AD. The aim of this study was to test interactions between life satisfaction and genetic predisposition on the future incidence of AD diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were used from 66,668 participants aged 60+ from the UK Biobank. Participants attended an assessment centre at baseline, and data were linked to hospital admissions data and death records up to 14\u00a0years later. Cox proportional hazards models were used to test interactions between life satisfaction and a polygenic risk score (PRS) for AD on incident AD diagnosis. Models were also run stratified by genetic risk for AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Models adjusted for age, sex, ethnicity, deprivation, education, and depression showed main effects of both life satisfaction (OR\u00a0=\u00a00.78, 95% CI\u00a0=\u00a00.68\u20130.90,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001) and the AD PRS (OR\u00a0=\u00a02.26, 95% CI\u00a0=\u00a02.12\u20132.40,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) on incident AD. There was a significant interaction between the two (OR\u00a0=\u00a01.21, 95% CI\u00a0=\u00a01.09\u20131.35,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Stratified models showed that life satisfaction was associated with lower incident AD in the low, but not in the high genetic risk group (low: OR\u00a0=\u00a00.56, 95% CI\u00a0=\u00a00.42\u20130.75,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001; high: OR\u00a0=\u00a00.88, 95% CI\u00a0=\u00a00.75\u20131.04,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.13).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Results show that genetic risk for AD modified the relationship between life satisfaction and the risk of AD. This suggests that genetic risk may weaken associations between life satisfaction and AD risk. The findings clarify the mixed results of previous research on this topic and may contribute to more tailored approaches to the prevention of AD in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/gps.70120","type":"journal-article","created":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T11:24:04Z","timestamp":1751196244000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Understanding Interactions Between Life Satisfaction and Genetic Predisposition on Risk of Alzheimer's Disease up to 14\u00a0Years Later: Findings From the UK Biobank"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8207-7698","authenticated-orcid":false,"given":"Amber","family":"John","sequence":"first","affiliation":[{"name":"Psychology Department University of Liverpool  Liverpool UK"},{"name":"ADAPT Lab Research Department of Clinical Educational and Health Psychology UCL  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4221-1546","authenticated-orcid":false,"given":"Roopal","family":"Desai","sequence":"additional","affiliation":[{"name":"ADAPT Lab Research Department of Clinical Educational and Health Psychology UCL  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Bartres\u2010Faz","sequence":"additional","affiliation":[{"name":"ADAPT Lab Research Department of Clinical Educational and Health Psychology UCL  London UK"},{"name":"Faculty of Medicine and Health Sciences Institute of Neurosciences University of Barcelona and Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorina","family":"Cadar","sequence":"additional","affiliation":[{"name":"CEDAR Lab Department of Clinical Neuroscience Brighton and Sussex Medical School (BSMS) University of Sussex  Brighton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darya","family":"Gaysina","sequence":"additional","affiliation":[{"name":"EDGE Lab School of Psychology University of Sussex  Brighton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida Suarez","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Dementia Research Centre UCL  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie L.","family":"Marchant","sequence":"additional","affiliation":[{"name":"Division of Psychiatry UCL  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Willroth","sequence":"additional","affiliation":[{"name":"Psychological &amp; Brain Sciences Washington University in St. Louis  St. Louis Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Richards","sequence":"additional","affiliation":[{"name":"MRC Unit for Lifelong Health and Ageing at UCL University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob","family":"Saunders","sequence":"additional","affiliation":[{"name":"CORE Data Lab Research Department of Clinical Centre for Outcomes and Research Effectiveness Educational and Health Psychology UCL  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1361-053X","authenticated-orcid":false,"given":"Joshua","family":"Stott","sequence":"additional","affiliation":[{"name":"ADAPT Lab Research Department of Clinical Educational and Health Psychology UCL  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,29]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Alzheimer\u2019s Society. \u201cAlzheimer\u2019s Disease \u201d (2023) https:\/\/www.alzheimers.org.uk\/about\u2010dementia\/types\u2010dementia\/alzheimers\u2010disease."},{"key":"e_1_2_11_3_1","unstructured":"World Health Organisation. \u201cDementia \u201d (2023) https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/dementia."},{"key":"e_1_2_11_4_1","unstructured":"Alzheimer\u2019s Research UK. \u201cThe Impact of Dementia \u201d (2023) https:\/\/dementiastatistics.org\/about\u2010dementia\/impact\/."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(24)01296\u20100"},{"key":"e_1_2_11_6_1","first-page":"5","article-title":"The Positive Side of Mental Health: Life Satisfaction in Later Life","volume":"10","author":"George L. K.","year":"1986","journal-title":"Generations: Journal of the American Society on Aging"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101594"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13523"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/s1041610215002422"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010160862"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbac064"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4849"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1578"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2019.03.005"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(97)07541\u20107"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201092304\u2010x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000271395.29695.9a"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12680"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.9879"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.8.906"},{"key":"e_1_2_11_21_1","unstructured":"UK Biobank. \u201cAlgorithmically Defined Outcomes (ADOs) \u201d (2022) https:\/\/biobank.ctsu.ox.ac.uk\/crystal\/refer.cgi?id=460."},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010019\u201000499\u20101"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0307270"},{"key":"e_1_2_11_24_1","first-page":"2006","article-title":"UK Biobank Release and Systematic Evaluation of Optimised Polygenic Risk Scores for 53 Diseases and Quantitative Traits","author":"Thompson D. J.","year":"2022","journal-title":"medRxiv"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010014\u20100726\u20104"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102380"},{"key":"e_1_2_11_27_1","first-page":"46","article-title":"Physiological Biomarkers of Chronic Stress: A Systematic Review","volume":"15","author":"Noushad S.","year":"2021","journal-title":"International Journal of Health Sciences"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00043"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14071"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14049"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1017\/thg.2016.65"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1017\/s003329172100502x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsyhores.2021.110529"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.04.001"},{"key":"e_1_2_11_35_1","unstructured":"Alzheimer\u2019s Research UK. \u201cDiagnosis of Dementia \u201d (2024) https:\/\/dementiastatistics.org\/about\u2010dementia\/diagnosis\/."},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbad020"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.70120","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/gps.70120","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.70120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T10:13:58Z","timestamp":1775643238000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.70120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,29]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/gps.70120"],"URL":"https:\/\/doi.org\/10.1002\/gps.70120","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,29]]},"assertion":[{"value":"2025-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70120"}}