{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:38:06Z","timestamp":1791995886610,"version":"4.4.0"},"reference-count":60,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cognitive decline commonly co\u2010occurs with dynamic physical and mental health changes in older adults. While early\u2010life adversity has been linked to various later\u2010life health outcomes, its relationship with cognitive function considering different health trajectories remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify distinct clusters of physical\u2010mental\u2010cognitive health trajectories among Chinese older adults and to examine the association between childhood adversities and cognitive function across these trajectories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using data from the China Health and Retirement Longitudinal Study (2011\u20132020), we included 6178 adults aged \u2265\u00a060\u00a0years. Latent Class Growth Modeling was used to identify trajectory patterns of functional limitations, depressive symptoms, and cognitive function. Mixed linear models examined associations between childhood adversities and cognitive function overall and across different identified trajectory patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four distinct trajectory classes were identified: healthy individuals (59.8%), rapid cognitive decline with gradual physical\u2010mental decline (16.5%), mild cognitive decline with physical\u2010mental improvement (14.4%), and moderate cognitive decline with rapid physical and moderate mental decline (9.4%). Experience of multiple childhood adversities was significantly associated with lower cognitive function (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.36, 95% CI [\u22120.58, \u22120.14]), independent of adulthood factors and consistent across various trajectory patterns. Among individuals showing rapid cognitive decline with gradual physical\u2010mental deterioration, experiencing two childhood adversities predicted lower cognitive function (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.88, 95% CI [\u22121.62, \u22120.14]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Childhood adversities are associated with cognitive impairment regardless of physical\u2010mental\u2010cognitive health trajectories in older Chinese adults. These findings highlight the long\u2010term impact of early\u2010life experiences on cognitive health in later life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/gps.70162","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T05:40:26Z","timestamp":1760420426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Childhood Adversity and Cognitive Function Across Physical\u2010Mental\u2010Cognitive Health Trajectories: A 10\u2010Year Longitudinal Study of Chinese Older Adults"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3988-0662","authenticated-orcid":false,"given":"Yin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Public Health City University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazhou","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Cambridge  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanquan","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Public Health University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(14)61347\u20107"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202009\u20103381OC"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889\u2010021\u201011068\u20101"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406\u2010021\u201001315\u20102"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13030376"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.2010.03171.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010024\u201003642\u20102"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010023\u201003847\u20109"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2019.0521"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glz147"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2024.101198"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2105\/ajph.2007.113886"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/ADR\u2010200232"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666\u20107568(23)00195\u20102"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010021\u201001269\u2010y"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2023.1240630"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41525\u2010019\u20100113\u20108"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12180"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2019.09.003"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/26335565221143012"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/gnp034"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.924281"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2021.07.039"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph14060582"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1353\/dem.2007.0033"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035\u2010023\u201000355\u2010z"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2010.05.013"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2022.935254"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010017\u20100895\u20104"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u20108624.2011.01641.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10433\u2010021\u201000608\u20108"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbae083"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys203"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010221093"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2024.101106"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010025\u201000836\u2010y"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jeoa.2013.11.001"},{"key":"e_1_2_11_39_1","volume-title":"Chapter 20 \u2010 Assessment of Nutritional Status in the Elderly, Causes and Management of Malnutrition in the Elderly","author":"Malazonia M.","year":"2021"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)01296\u20100"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.112.118307"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph182211818"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-0753-5"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155431"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1132908"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0226773"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.10.012"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751\u20109004.2007.00054.x"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/0095798420930932"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afab191"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010019\u20100244\u20107"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/psy.0b013e3181907c1b"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.09.001"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/07334648211058718"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwab019"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.02.062"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ssmph.2021.100767"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2016.02.026"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/0164027504268574"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/geroni\/igad028"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chieco.2023.101932"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.70162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:13:00Z","timestamp":1761657180000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.70162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":60,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/gps.70162"],"URL":"https:\/\/doi.org\/10.1002\/gps.70162","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70162"}}