{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T06:17:40Z","timestamp":1774592260974,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>GBA<\/jats:italic>\n                      variant confers increased risk of synuclein disorders but it is unclear what impact it has in pre\u2010clinical groups. This study aimed to identify early psychiatric and cognitive manifestations amongst pre\u2010clinical\n                      <jats:italic>GBA<\/jats:italic>\n                      carriers in a community cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      This study used data from the PROTECT\u2010UK cohort to compare 388\n                      <jats:italic>GBA<\/jats:italic>\n                      carriers (N370S, E326K and T369M) without Parkinson's disease to age\u2010matched controls. Neuropsychiatric symptoms (NPS) were measured with the Mild Behaviour Impairment Checklist, and cognition was measured using computerised neuropsychology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:bold>Results:<\/jats:bold>\n                      <jats:italic>GBA<\/jats:italic>\n                      carriers over 70 had significantly increased NPS compared with controls (\n                      <jats:italic>z<\/jats:italic>\n                      \u00a0=\u00a02.13,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03). There was no difference between carriers and non\u2010carriers in younger individuals but a sub\u2010group comparison in the overall cohort showed that NPS were more severe in quartile four (Q4) of carriers compared to Q4 of controls (\n                      <jats:italic>z<\/jats:italic>\n                      \u00a0=\u00a02.39,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.017), indicating an increase in NPS in this sub\u2010group across a broader age range. No differences in cognition were seen.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings suggest that NPS may be an early clinical manifestation of emerging synucleinopathy amongst individuals prior to diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/gps.70189","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T17:04:22Z","timestamp":1773939862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synuclein Disorder\u2010Related Genetic Determinants of Mild Behavioural Impairment in a Pre\u2010Clinical Community Cohort"],"prefix":"10.1002","volume":"41","author":[{"given":"Millie","family":"Sander\u2010Long","sequence":"first","affiliation":[{"name":"Faculty of Life Sciences College of Medicine &amp; Health University of Exeter  Exeter UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6490-6037","authenticated-orcid":false,"given":"Byron","family":"Creese","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences College of Medicine &amp; Health University of Exeter  Exeter UK"},{"name":"Department of Life Sciences Brunel University London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Corbett","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences College of Medicine &amp; Health University of Exeter  Exeter UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Rosenzweig","sequence":"additional","affiliation":[{"name":"Sleep Disorders Centre Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Cummings","sequence":"additional","affiliation":[{"name":"Department of Brain Health Chambers\u2010Grundy Center for Transformative Neuroscience School of Integrated Health Sciences University of Nevada  Las Vegas Nevada USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clive","family":"Ballard","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences College of Medicine &amp; Health University of Exeter  Exeter UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(21)00330\u20106"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11081261"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2023.11.001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.1593"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2024.106981"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20676"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae188"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.1925"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26593"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010210365"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.08.059"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000001315"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531\u2010025\u201001060\u20106"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102020\u2010322857"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.635958"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.06.010"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12164"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010160979"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010180131"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12098"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12386"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010023\u201000631\u20106"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2019.104502"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2019.10.007"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010024\u201001007\u20101"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1997.00550160091022"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.70189","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/gps.70189","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.70189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:56:08Z","timestamp":1774587368000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.70189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/gps.70189"],"URL":"https:\/\/doi.org\/10.1002\/gps.70189","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70189"}}