{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:10:30Z","timestamp":1789474230397,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013139","name":"Humanities and Social Science Fund of Ministry of Education of China","doi-asserted-by":"publisher","award":["2022ZD0211603"],"award-info":[{"award-number":["2022ZD0211603"]}],"id":[{"id":"10.13039\/501100013139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371188"],"award-info":[{"award-number":["82371188"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2022YFC3603000"],"award-info":[{"award-number":["2022YFC3603000"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Although hearing loss is a well\u2010established risk factor for dementia, previous studies predominantly focused on peripheral hearing sensitivity, overlooking deficits in central auditory processing as measured by speech\u2010in\u2010noise (SIN) testing. This study aims to investigate the association between bilateral SIN hearing loss and the risk of all\u2010cause dementia, and to examine how cognitive reserve (CR) modifies this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective cohort study utilizing data from the UK Biobank, a large, population\u2010based cohort. Participants were recruited between 2006 and 2010, with follow\u2010up lasting until October 2023. The primary outcome was all\u2010cause dementia, and secondary outcomes included some brain regions of interest. Cox proportional\u2010hazards models were employed to estimate dementia risk and differences in brain volume associated with bilateral SIN hearing status, as well as the interaction between SIN hearing and CR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 72,004 participants, both bilateral hearing loss (HR\u00a0=\u00a01.507, 95% CI: 1.349, 1.685) and unilateral hearing loss (HR\u00a0=\u00a01.181, 95% CI: 1.068, 1.305) were associated with higher dementia risk. Bilateral hearing loss was significantly associated with volume in brain regions supporting auditory, including subcortical volumes, regional gray matter volumes, accumbens, hippocampus, central opercular cortex, and heschl's gyrus. Right ear dominance was observed in unilateral mild hearing loss, whereas unilateral severe hearing loss demonstrated left ear dominance. Although dementia risk showed a dose\u2010response relationship according to the level of SIN hearing and CR, there was no evidence that CR significantly moderated the association between SIN hearing and dementia risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study highlights significant disparities in dementia risk and brain volume based on bilateral hearing status, and hearing conservation strategies should consider hearing status laterality and severity to enhance prevention precision.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/gps.70199","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:46:58Z","timestamp":1772988418000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Unilateral and Bilateral Speech\u2010In\u2010Noise Hearing Status With Dementia"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1300-901X","authenticated-orcid":false,"given":"Haoxiang","family":"Lang","sequence":"first","affiliation":[{"name":"Department of Neurology Fujian Institute of Geriatrics Union Hospital of Fujian Medical University  Fuzhou China"},{"name":"Fujian Medical University Xiamen Humanity Hospital  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zirong","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Neurology Fujian Institute of Geriatrics Union Hospital of Fujian Medical University  Fuzhou China"},{"name":"Fujian Key Laboratory of Molecular Neurology Institute of Neuroscience Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoman","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bihao","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Neurology Fujian Institute of Geriatrics Union Hospital of Fujian Medical University  Fuzhou China"},{"name":"Fujian Key Laboratory of Molecular Neurology Institute of Neuroscience Fujian Medical University  Fuzhou China"},{"name":"Institute of Clinical Neurology Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Fujian Institute of Geriatrics Union Hospital of Fujian Medical University  Fuzhou China"},{"name":"Fujian Key Laboratory of Molecular Neurology Institute of Neuroscience Fujian Medical University  Fuzhou China"},{"name":"Institute of Clinical Neurology Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9895-3234","authenticated-orcid":false,"given":"Ya","family":"Fang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Health Technology Assessment of Fujian Province School of Public Health Xiamen University  Xiamen China"},{"name":"National Institute for Data Science in Health and Medicine Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6794-1750","authenticated-orcid":false,"given":"Jiawei","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Neurology Fujian Institute of Geriatrics Union Hospital of Fujian Medical University  Fuzhou China"},{"name":"Fujian Key Laboratory of Molecular Neurology Institute of Neuroscience Fujian Medical University  Fuzhou China"},{"name":"Institute of Clinical Neurology Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(24)01296\u20100"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.26320"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913\u2010020\u201005977\u2010x"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2666\u20107568(20)30004\u20100"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102346"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12416"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010024\u201008620\u20101"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00622"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2025.07.003"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.2471\/blt.21.285643"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.100963"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.08.003"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glz035"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2017.2513"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/s1041610219001662"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.07.219"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/14992027.2021.1902579"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00326"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/aud.0000000000000010"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010019\u201000499\u20101"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjo.2023.634"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12499"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2024.13"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010024\u201001528\u20102"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0000000000004710"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2666\u20107568(23)00232\u20105"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.765584"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010024\u201002385\u2010x"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010024\u201003640\u20104"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531\u2010024\u201000810\u20102"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489420952467"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.362"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glw069"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2021.62.5.446"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1424746"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.09.020"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.12.059"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.07.005"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep25811"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00206"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2014.07.006"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000304345.14212.38"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a035493"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(17)31363\u20106"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx246"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyae054"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.70199","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/gps.70199","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.70199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:56:15Z","timestamp":1774587375000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.70199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/gps.70199"],"URL":"https:\/\/doi.org\/10.1002\/gps.70199","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]},"assertion":[{"value":"2025-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70199"}}