{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:38:11Z","timestamp":1777430291644,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["3165563"],"award-info":[{"award-number":["3165563"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Psychiatric comorbidities are common in Alzheimer's disease (AD), and they have a negative impact on quality of life, but their impact on mortality remains unclear. This study examined mortality among persons with AD and psychiatric morbidity compared to persons with AD without psychiatric morbidity. This is the first study to analyze Alzheimer's disease mortality based on the timing of earlier psychiatric morbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We utilized the nationwide register\u2010based MEDALZ cohort, including 70,718 Finnish individuals diagnosed with AD between 2005 and 2011. Individuals were categorized into four groups based on the occurrence of their hospital\u2010treated psychiatric diagnosis before the diagnosis of AD. Mortality was assessed over an 8\u2010year follow\u2010up. Chi\u2010square test was used to compare the differences between the four groups in terms of causes of death and annual cumulative mortality. We determined cumulative mortality curves and hazard ratios, stratified by age, gender, cardiovascular disease, and the year of AD diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the 8\u2010year follow\u2010up, 70.4% of the AD cohort had died. Persons with earlier psychiatric morbidity had an AD diagnosis 1.4\u20134.3\u00a0years earlier and died 1.4\u20134.1\u00a0years younger. Mortality risk was slightly higher among those with psychiatric morbidity compared to those without (adjusted HRs 1.03\u20131.41), with the effect decreasing over the years of follow\u2010up. Mortality risk was not affected by the timing of psychiatric morbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Psychiatric comorbidity is associated with earlier AD onset and reduced lifespan; however, post\u2010diagnosis survival appears to be largely determined by AD progression itself.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/gps.70210","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T09:43:22Z","timestamp":1775814202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mortality of People With Alzheimer's Disease and Psychiatric Morbidity: A Nationwide Finnish Cohort Study"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6728-0746","authenticated-orcid":false,"given":"Aleksi","family":"Alastalo","sequence":"first","affiliation":[{"name":"Research Unit of Population Health University of Oulu  Oulu Finland"},{"name":"Medical Research Center Oulu Oulu University Hospital and University of Oulu  Oulu Finland"},{"name":"School of Pharmacy University of Eastern Finland  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Haapea","sequence":"additional","affiliation":[{"name":"Research Unit of Population Health University of Oulu  Oulu Finland"},{"name":"Medical Research Center Oulu Oulu University Hospital and University of Oulu  Oulu Finland"},{"name":"School of Pharmacy University of Eastern Finland  Kuopio Finland"},{"name":"Department of Psychiatry Oulu University Hospital Wellbeing Services County of North Ostrobothnia  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Nordstr\u00f6m","sequence":"additional","affiliation":[{"name":"Research Unit of Population Health University of Oulu  Oulu Finland"},{"name":"Medical Research Center Oulu Oulu University Hospital and University of Oulu  Oulu Finland"},{"name":"Department of Psychiatry Oulu University Hospital Wellbeing Services County of North Ostrobothnia  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9270-9268","authenticated-orcid":false,"given":"Anna\u2010Maija","family":"Tolppanen","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Eastern Finland  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jouko","family":"Miettunen","sequence":"additional","affiliation":[{"name":"Research Unit of Population Health University of Oulu  Oulu Finland"},{"name":"Medical Research Center Oulu Oulu University Hospital and University of Oulu  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miika","family":"Nietola","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Turku  Turku Finland"},{"name":"Turku University Hospital  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirpa","family":"Hartikainen","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Eastern Finland  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"J\u00e4\u00e4skel\u00e4inen","sequence":"additional","affiliation":[{"name":"Research Unit of Population Health University of Oulu  Oulu Finland"},{"name":"Medical Research Center Oulu Oulu University Hospital and University of Oulu  Oulu Finland"},{"name":"Department of Psychiatry Oulu University Hospital Wellbeing Services County of North Ostrobothnia  Oulu 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