{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T08:03:15Z","timestamp":1779868995954,"version":"3.53.1"},"reference-count":99,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Late\u2010life depression (LLD) is a heterogeneous psychiatric condition characterized by a wide range of psychopathological symptoms and associated with functional and structural abnormalities in brain networks implicated in mood and cognitive regulation. This cross\u2010sectional study investigated the relationship between specific depressive symptom dimensions and cortical brain measures, as assessed by magnetic resonance imaging, in a sample of 87 community\u2010dwelling older adults with depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant associations were identified between the severity of sad mood and reduced cortical volume in the right medial orbitofrontal cortex (OFC) (\n                      <jats:italic>p<\/jats:italic>\n                      [FDR]\u00a0=\u00a00.047), as well as reduced cortical thickness in the left OFC (\n                      <jats:italic>p<\/jats:italic>\n                      [FDR]\u00a0=\u00a00.008), left ventrolateral prefrontal cortex (VLPFC) (\n                      <jats:italic>p<\/jats:italic>\n                      [FDR]\u00a0=\u00a00.02), and right dorsolateral prefrontal cortex (DLPFC) (\n                      <jats:italic>p<\/jats:italic>\n                      [FDR]\u00a0=\u00a00.054). Apathy\/lassitude was also significantly associated with reduced thickness in the left OFC (\n                      <jats:italic>p<\/jats:italic>\n                      [FDR]\u00a0=\u00a00.016) and left VLPFC (\n                      <jats:italic>p<\/jats:italic>\n                      [FDR]\u00a0=\u00a00.046). Moreover, overall depression severity correlated with reduced thickness in the right middle temporal cortex (MTC) (\n                      <jats:italic>p<\/jats:italic>\n                      [FDR]\u00a0=\u00a00.035).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our results suggest that feelings of low mood and lassitude in LLD are linked to structural changes in brain regions involved in emotion regulation, motivational drive, self\u2010referential thinking, executive control, and decision\u2010making. The findings contribute to the understanding of the neurobiological underpinnings of LLD and support the hypothesis that symptom\u2010specific disruptions within mood and cognitive processing circuits are integral to its pathophysiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/gps.70218","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:03:54Z","timestamp":1777392234000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sad Mood in Late\u2010Life Depression Correlates With Reduced Thickness in Orbitofrontal Cortex"],"prefix":"10.1002","volume":"41","author":[{"given":"Julia C.","family":"Loureiro","sequence":"first","affiliation":[{"name":"Service of Interdisciplinary Neuromodulation Department and Institute of Psychiatry University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"},{"name":"Laboratory of Neuroscience LIM\u201027 Department and Institute of Psychiatry University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"},{"name":"National Institute of Biomarkers in Psychiatry Department and Institute of Psychiatry University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Martins","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroscience LIM\u201044 Radiology Institute Hospital das Cl\u00ednicas HCFMUSP Faculty of Medicine University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro da C. 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