{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T12:39:42Z","timestamp":1725539982279},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2002,9,30]],"date-time":"2002-09-30T00:00:00Z","timestamp":1033344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cross\u2010sectional studies indicate that, in comparison to younger patients, older schizophrenic patients have a higher risk for neuroleptic\u2010induced Parkinsonism and tardive dyskinesia (TD). It has been suggested, therefore, that older patients with schizophrenia could be maintained on reduced doses of conventional neuroleptics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We examined the effect of age on psychopharmacological management in a naturalistic study of a group of 165 patients with a clinical diagnosis of schizophrenia or a related psychotic disorder (age range=21\u201384 years; subjects \u22651;45 years <jats:italic>n<\/jats:italic>=86) treated with either haloperidol decanoate or fluphenazine decanoate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increasing age was not correlated with total daily dose of neuroleptics or anticholinergic medication. However, a modest negative correlation of age with daily neuroleptic dose was found in patients aged 45 years and older.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study highlight the need for prospective assessments of depot neuroleptic dose requirements in older patients suffering from primary psychotic disorders. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.740","type":"journal-article","created":{"date-parts":[[2002,10,29]],"date-time":"2002-10-29T14:00:53Z","timestamp":1035900053000},"page":"1012-1017","source":"Crossref","is-referenced-by-count":13,"title":["The effect of age on the pharmacological management of ambulatory patients treated with depot neuroleptic medications for schizophrenia and related psychotic disorders"],"prefix":"10.1002","volume":"17","author":[{"given":"David C.","family":"Mamo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Sweet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. N.","family":"Roy Chengappa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravinder R.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilip V.","family":"Jeste","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,10,3]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Clinical Handbook of Psychotropic Drugs","author":"Bezchlibnyk\u2010Butler KZ","year":"1995"},{"key":"e_1_2_1_3_1","first-page":"546","volume-title":"Schizophrenia","author":"Casey DE","year":"1995"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1974.01760090055009"},{"issue":"11","key":"e_1_2_1_5_1","first-page":"73","article-title":"Expert consensus treatment guidelines for schizophrenia: a guide for patients and families","volume":"60","author":"Expert Consensus Group","year":"1999","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_1_6_1","volume-title":"ECDEU Assessment Manual for Psychopharmacology, Revised, DHEW Pub. 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