{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:20:50Z","timestamp":1786116050430,"version":"build-2736575974"},"reference-count":73,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Gen. Psychiatry"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Identifying reliable predictors for dementia remains a critical unmet need. Light exposure plays a crucial role in regulating circadian rhythms, which influence cognitive function. However, the association between light exposure and dementia risk remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study examined the associations of daytime and nighttime light exposure with dementia risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 87\u00a0577 dementia\u2010free participants (mean age: 62.36\u00a0years; 56.98% female) were included. Daytime and nighttime light exposures were measured using 7\u2010day free\u2010living wrist\u2010worn accelerometry. Incident dementia was identified from primary care, hospital inpatient admissions and death registry data. Cox proportional hazards models assessed associations, and mediation analyses evaluated circadian rest\u2013activity rhythms (CRARs), brain structures and vitamin D as potential mediators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over a median follow\u2010up of 8.1\u00a0years, 741 participants developed dementia. Daytime light exposure above 1000 lux was associated with reduced dementia risk (hazard ratio [HR] 0.84, 95% confidence interval [CI] 0.71\u20130.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.039). Longer exposure to brighter light (e.g.,\u00a0\u2265\u00a00.70\u00a0h at\u00a0\u2265\u00a05000 lux; HR 0.83,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.036) was associated with a further reduction in risk. In exploratory analyses, CRARs and brain structures mediated up to 33% of the association. Protective associations were stronger in those with high levels of nighttime light exposure, an evening chronotype or\n                      <jats:italic>apolipoprotein E (APOE)<\/jats:italic>\n                      \u03b54 carrier status, with a risk reduction of up to 41%. Furthermore,\u00a0&lt;\u00a00.70\u00a0h per day of bright daytime light (\u2265\u00a05000 lux) outperformed six established dementia predictors (e.g.,\u00a0obesity, alcohol consumption, traumatic brain injury and so on). Nighttime light showed no significant association with dementia risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High levels of daytime light exposure were significantly associated with lower dementia risk. Further research should explore its role in dementia screening and inform the development of light\u2010based interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/gps3.70039","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T07:02:15Z","timestamp":1782284535000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations between wearable\u2010device\u2010measured daytime and nighttime light exposures and dementia risk: A prospective cohort study"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9683-7945","authenticated-orcid":false,"given":"Nana","family":"Zheng","sequence":"first","affiliation":[{"name":"Institute of Neuropsychiatry, The Affiliated Brain Hospital, Guangzhou Medical University  Guangzhou Guangdong China"},{"name":"Key Laboratory of Sleep and Biological Rhythms of Guangdong Province, Center for Sleep and Circadian Medicine The Affiliated Brain Hospital, Guangzhou Medical University  Guangzhou Guangdong China"},{"name":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4206-9298","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Sleep and Biological Rhythms of Guangdong Province, Center for Sleep and Circadian Medicine The Affiliated Brain Hospital, Guangzhou Medical University  Guangzhou Guangdong China"},{"name":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders  Guangzhou Guangdong China"},{"name":"School of Basic Medical Sciences Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7885-0353","authenticated-orcid":false,"given":"Biao","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Sleep and Biological Rhythms of Guangdong Province, Center for Sleep and Circadian Medicine The Affiliated Brain Hospital, Guangzhou Medical University  Guangzhou Guangdong China"},{"name":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4652-8036","authenticated-orcid":false,"given":"Xionge","family":"Mei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Sleep and Biological Rhythms of Guangdong Province, Center for Sleep and Circadian Medicine The Affiliated Brain Hospital, Guangzhou Medical University  Guangzhou Guangdong China"},{"name":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[{"name":"Centre for Preventive Neurology Wolfson Institute of Population Health, Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0780-826X","authenticated-orcid":false,"given":"Jing","family":"Du","sequence":"additional","affiliation":[{"name":"Key Laboratory of Sleep and Biological Rhythms of Guangdong Province, Center for Sleep and Circadian Medicine The Affiliated Brain Hospital, Guangzhou Medical University  Guangzhou Guangdong China"},{"name":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngan Yin","family":"Chan","sequence":"additional","affiliation":[{"name":"Li Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine The Chinese University of Hong Kong  Shatin Hong Kong China"},{"name":"Li Ka Shing Institute of Health Sciences, Faculty of Medicine The Chinese University of Hong Kong  Shatin Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joey W. 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