{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T16:19:12Z","timestamp":1788970752185,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"vor","delay-in-days":63,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hastings Center Report"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Optimistic predictions that genetic and genomic testing will provide health benefits have been tempered by the concern that individuals who receive their results may experience negative psychosocial outcomes. This potential ethical and clinical concern has prompted extensive conversations between policy\u2010makers, health researchers, ethicists, and the general public. Fortunately, the psychosocial consequences of such testing are subject to empirical investigation, and over the past quarter century, research that clarifies some of the types, likelihood, and severity of potential harms from learning the results of the testing has accumulated. I aim to provide an overview of the findings of this research by looking at selected systematic reviews. This will convey the gist of the literature\u2019s quality and coverage, reveal gaps in existing knowledge, and highlight promising areas for future scholarship.<\/jats:italic>\n                  <\/jats:p>","DOI":"10.1002\/hast.1021","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T11:25:02Z","timestamp":1562153102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["What Is the Psychosocial Impact of Providing Genetic and Genomic Health Information to Individuals?\n                    <i>An Overview of Systematic Reviews<\/i>"],"prefix":"10.1002","volume":"49","author":[{"given":"Christopher H.","family":"Wade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,3]]},"reference":[{"key":"e_1_2_14_1_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579400007318"},{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-014-9755-y"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3235"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e31815f524f"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2009.0029"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-010-9327-8"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.4378"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.181"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201883"},{"key":"e_1_2_14_10_1","first-page":"211","volume-title":"The Code of Codes: Scientific and Social Issues in the Human Genome Project","author":"Wexler N.","year":"1992"},{"key":"e_1_2_14_11_1","unstructured":"Crozier Robertson and Dale \u201cThe Psychological Impact of Predictive Genetic Testing for Huntington\u2019s Disease.\u201d"},{"key":"e_1_2_14_12_1","unstructured":"Wexler \u201cClairvoyance and Caution.\u201d"},{"key":"e_1_2_14_13_1","unstructured":"Crozier Robertson and Dale \u201cThe Psychological Impact of Predictive Genetic Testing for Huntington\u2019s Disease.\u201d"},{"key":"e_1_2_14_14_1","unstructured":"Ibid."},{"key":"e_1_2_14_15_1","unstructured":"Heinigeret al. \u201cDistress in Unaffected Individuals.\u201d"},{"key":"e_1_2_14_16_1","unstructured":"Heshkaet al. \u201cA Systematic Review of Perceived Risks Psychological and Behavioral Impacts of Genetic Testing.\u201d"},{"key":"e_1_2_14_17_1","unstructured":"Ibid."},{"key":"e_1_2_14_18_1","unstructured":"Vansenne Bossuyt and de Borgie \u201cEvaluating the Psychological Effects.\u201d"},{"key":"e_1_2_14_19_1","unstructured":"Lewis Skirton and Jones \u201cCan We Make Assumptions about the Psychosocial Impact of Living as a Carrier?\u201d"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hast.1019"},{"key":"e_1_2_14_21_1","unstructured":"Covoloet al. \u201cInternet\u2010Based Direct\u2010to\u2010Consumer Genetic Testing.\u201d"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2012.176"},{"key":"e_1_2_14_23_1","unstructured":"Wakefieldet al. \u201cThe Psychological Impact of Genetic Information on Children.\u201d"},{"key":"e_1_2_14_24_1","unstructured":"Gaffet al. \u201cProcess and Outcome in Communication of Genetic Information.\u201d"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-7-10"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(95)00062-3"},{"key":"e_1_2_14_27_1","unstructured":"Grob \u201cQualitative Research on Expanded Prenatal and Newborn Screening.\u201d"},{"key":"e_1_2_14_28_1","unstructured":"Lewis Skirton and Jones \u201cCan We Make Assumptions about the Psychosocial Impact of Living as a Carrier?\u201d; Gaff et al. \u201cProcess and Outcome in Communication of Genetic Information.\u201d"},{"key":"e_1_2_14_29_1","unstructured":"Lewis Skirton and Jones \u201cCan We Make Assumptions about the Psychosocial Impact of Living as a Carrier?\u201d; Crozier Robertson and Dale \u201cThe Psychological Impact of Predictive Genetic Testing for Huntington\u2019s Disease.\u201d"},{"key":"e_1_2_14_30_1","unstructured":"Covoloet al. \u201cInternet\u2010Based Direct\u2010to\u2010Consumer Genetic Testing\u201d; Heiniger et al. \u201cDistress in Unaffected Individuals\u201d; Lewis Skirton and Jones \u201cCan We Make Assumptions about the Psychosocial Impact of Living as a Carrier?\u201d; Wakefield et al. \u201cThe Psychological Impact of Genetic Information on Children.\u201d"},{"key":"e_1_2_14_31_1","unstructured":"Vansenne Bossuyt and de Borgie \u201cEvaluating the Psychological Effects\u201d; Gaff et al. \u201cProcess and Outcome in Communication of Genetic Information.\u201d"},{"key":"e_1_2_14_32_1","unstructured":"Lewis Skirton and Jones \u201cCan We Make Assumptions about the Psychosocial Impact of Living as a Carrier?\u201d"},{"key":"e_1_2_14_33_1","unstructured":"Covoloet al. \u201cInternet\u2010Based Direct\u2010to\u2010Consumer Genetic Testing.\u201d"},{"key":"e_1_2_14_34_1","unstructured":"Crozier Robertson and Dale \u201cThe Psychological Impact of Predictive Genetic Testing for Huntington\u2019s Disease.\u201d"},{"key":"e_1_2_14_35_1","unstructured":"Ibid.;Covoloet al. \u201cInternet\u2010Based Direct\u2010to\u2010Consumer Genetic Testing;\u201d Heshka et al. \u201cA Systematic Review of Perceived Risks\u201d; Lewis Skirton and Jones \u201cCan We Make Assumptions about the Psychosocial Impact of Living as a Carrier?\u201d; Gaff et al. \u201cProcess and Outcome in Communication of Genetic Information.\u201d"},{"key":"e_1_2_14_36_1","unstructured":"Covoloet al. \u201cInternet\u2010Based Direct\u2010to\u2010Consumer Genetic Testing\u201d; Crozier Robertson and Dale \u201cThe Psychological Impact of Predictive Genetic Testing for Huntington\u2019s Disease\u201d; Heshka et al. \u201cA Systematic Review of Perceived Risks.\u201d"},{"key":"e_1_2_14_37_1","unstructured":"Heshkaet al. \u201cA Systematic Review of Perceived Risks\u201d; Gaff et al. \u201cProcess and Outcome in Communication of Genetic Information\u201d; Heiniger et al. \u201cDistress in Unaffected Individuals.\u201d"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-197905000-00004"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hast.1015"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hast.1012"}],"container-title":["Hastings Center Report"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhast.1021","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hast.1021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T01:39:06Z","timestamp":1694309946000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hast.1021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":40,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1002\/hast.1021"],"URL":"https:\/\/doi.org\/10.1002\/hast.1021","archive":["Portico"],"relation":{},"ISSN":["0093-0334","1552-146X"],"issn-type":[{"value":"0093-0334","type":"print"},{"value":"1552-146X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"2019-07-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}