{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T17:47:50Z","timestamp":1725644870997},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T00:00:00Z","timestamp":1421625600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hastings Center Report"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Lantos and Feudtner argue that SUPPORT was an instance of CER and that CER differs from research involving unproven, experimental therapies because it exposes research subjects to the same risks patients regularly face in clinical practice. Like many defenders of SUPPORT, they formally acknowledge the study as research but want it to be thought of as clinical care. They develop an appealing argument, but it is misleading. Whatever doctors might have done in clinical practice, their choice of target range within the study and for study participants was influenced by research aims. Just as in research involving unproven, experimental therapies, the care of patients in SUPPORT was altered for the goal of obtaining knowledge to help future patients<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/hast.417","type":"journal-article","created":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T14:12:58Z","timestamp":1421763178000},"page":"44-45","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["SUPPORT and Comparative Effectiveness Trials: <i>What's at Stake?<\/i>"],"prefix":"10.1002","volume":"45","author":[{"given":"Lois","family":"Shepherd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,19]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"crossref","unstructured":"J. Lantos and C. Feudtner \u201cSUPPORT and the Ethics of Study Implementation: Lessons for Comparative Effectiveness Research from the Trial of Oxygen Therapy for Premature Babies \u201dHastings Center Report45 (2015): 30\u201340.","DOI":"10.1002\/hast.407"},{"key":"e_1_2_2_2_1","doi-asserted-by":"crossref","unstructured":"J. E. Tyson M. Walsh and C. T. D'Angio \u201cComparative Effectiveness Trials: Generic Misassumptions Underlying the SUPPORT Controversy \u201dPediatrics134 no. 4 (2014): 651\u20134 at 652.","DOI":"10.1542\/peds.2013-4176"},{"key":"#cr-split#-e_1_2_2_3_1.1","unstructured":"B. S. Wilfond et\u00a0al. \"The OHRP and SUPPORT \"New England Journal of Medicine368 (2012): e36"},{"key":"#cr-split#-e_1_2_2_3_1.2","doi-asserted-by":"crossref","unstructured":"R. Macklin et\u00a0al. \"The OHRP and SUPPORT-Another View \"New England Journal of Medicine369 (2013): e3(1-3).","DOI":"10.1056\/NEJMc1308015"},{"key":"e_1_2_2_4_1","unstructured":"J. Lantos President's Council on Bioethics meeting April 20 2006 session 4: \u201cChildren and Clinical Research \u201dhttps:\/\/bioeth\u2010icsarchive.georgetown.edu\/pcbe\/transcripts\/april06\/session4.html."},{"key":"#cr-split#-e_1_2_2_5_1.1","doi-asserted-by":"crossref","unstructured":"L. Shepherd and M. F. Riley \"In Plain Sight: A Solution to a Fundamental Challenge in Human Research Journal of Law Medicine and Ethics40 (2012): 970-89","DOI":"10.1111\/j.1748-720X.2012.00725.x"},{"key":"#cr-split#-e_1_2_2_5_1.2","doi-asserted-by":"crossref","unstructured":"E. H. Morreim \"Taking a Lesson from the Lawyers: Defining and Addressing Conflict of Interest \"'American Journal of Bioethics11 no. 1 (2011): 33-34.","DOI":"10.1080\/15265161.2010.534542"},{"key":"e_1_2_2_6_1","unstructured":"Lantos and Feudtner \u201cSUPPORT and the Ethics of Study Implementation \u201d 31."},{"key":"e_1_2_2_7_1","unstructured":"W. A. Carlo et\u00a0al. \u201cTarget Ranges of Oxygen Saturation in Extremely Preterm Infants \u201dNew England Journal of Medicine362 (2010): 1959\u201369. Some commentators have tried to deflect attention from this conclusion by pointing out that as a group babies in the study may have fared better than babies outside the study. Even if this is true the question of group harms or benefits does not address the question of individual harms or benefits which is the primary concern of individual participants or in this case their parents. Editorial \u201cSubject to Question \u201dNature500 (2013): 377."},{"key":"e_1_2_2_8_1","doi-asserted-by":"crossref","unstructured":"R. Macklin and L. Shepherd \u201cInformed Consent and Standard of Care: What Must Be Disclosed \u201dAmerican Journal of Bioethics13 (2013): 9\u201313.","DOI":"10.1080\/15265161.2013.849303"}],"container-title":["Hastings Center Report"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhast.417","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhast.417","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hast.417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T03:04:00Z","timestamp":1695611040000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hast.417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1002\/hast.417"],"URL":"https:\/\/doi.org\/10.1002\/hast.417","archive":["Portico"],"relation":{},"ISSN":["0093-0334","1552-146X"],"issn-type":[{"value":"0093-0334","type":"print"},{"value":"1552-146X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"2015-01-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}