{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:16:46Z","timestamp":1790288206859,"version":"4.1.0"},"reference-count":137,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T00:00:00Z","timestamp":1534204800000},"content-version":"vor","delay-in-days":44,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hastings Center Report"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Many scientists and doctors hope that affordable genome sequencing will lead to more personalized medical care and improve public health in ways that will benefit children, families, and society more broadly. One hope in particular is that all newborns could be sequenced at birth, thereby setting the stage for a lifetime of medical care and self\u2010directed preventive actions tailored to each child's genome. Indeed, commentators often suggest that universal genome sequencing is inevitable. Such optimism can come with the presumption that discussing the potential limits, cost, and downsides of widespread application of genomic technologies is pointless, excessively pessimistic, or overly cautious. We disagree. Given the pragmatic challenges associated with determining what sequencing data mean for the health of individuals, the economic costs associated with interpreting and acting on such data, and the psychosocial costs of predicting one's own or one's child's future life plans based on uncertain testing results, we think this hope and optimism deserve to be tempered<\/jats:italic>.<\/jats:p><jats:p><jats:italic>In the analysis that follows, we distinguish between two reasons for using sequencing: to diagnose individual infants who have been identified as sick and to screen populations of infants who appear to be healthy. We also distinguish among three contexts in which sequencing for either diagnosis or screening could be deployed: in clinical medicine, in public health programs, and as a direct\u2010to\u2010consumer service. Each of these contexts comes with different professional norms, policy considerations, and public expectations. Finally, we distinguish between two main types of genome sequencing: targeted sequencing, where only specific genes are sequenced or analyzed, and whole\u2010exome or whole\u2010genome sequencing, where all the DNA or all the coding segments of all genes are sequenced and analyzed<\/jats:italic>.<\/jats:p><jats:p><jats:italic>In a symptomatic newborn, targeted or genome\u2010wide sequencing can help guide other tests for diagnosis or for specific treatment that is urgently needed. Clinicians use the infant's symptoms (or phenotype) to interrogate the sequencing data. These same complexities and uncertainties, however, limit the usefulness of genome\u2010wide sequencing as a population screening tool. While we recognize considerable benefit in using targeted sequencing to screen for or detect specific conditions that meet the criteria for inclusion in newborn screening panels, use of genome\u2010wide sequencing as a sole screening tool for newborns is at best premature. We conclude that sequencing technology can be beneficially used in newborns when that use is nuanced and attentive to context<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/hast.874","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T14:56:47Z","timestamp":1534258607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Sequencing Newborns:<i>A Call for Nuanced Use of Genomic Technologies<\/i>"],"prefix":"10.1002","volume":"48","author":[{"given":"Josephine","family":"Johnston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Lantos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Goldenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Parens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Koenig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"members of the NSIGHT Ethics and Policy Advisory Board","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hast.614"},{"key":"e_1_2_8_3_1","article-title":"Francis Collins Says Medicine in the Future Will Be Tailored to Your Genes","author":"Collins F. S.","year":"2014","journal-title":"Wall Street Journal"},{"key":"e_1_2_8_4_1","article-title":"Routine Whole\u2010Genome Sequencing of Babies by 2019?","author":"MacArthur D. G.","year":"2009","journal-title":"Wired"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.2217\/pme.14.68"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1312543"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-017-0247-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des286"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1407349"},{"key":"e_1_2_8_8_1","unstructured":"Friedmanet\u00a0al. Genomic Newborn Screening;"},{"key":"e_1_2_8_8_2","first-page":"389","article-title":"American Academy of Pediatrics Newborn Screening Task Force, Serving the Family from Birth to the Medical Home, in Newborn Screening: A Blueprint for the Future\u2014A Call for a National Agenda on State Newborn Screening Programs","volume":"106","year":"2000","journal-title":"Pediatrics"},{"key":"e_1_2_8_9_1","unstructured":"Jeungstet\u00a0al. Personalized to Precision Medicine\u201d;"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/hast.65"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.73"},{"key":"e_1_2_8_11_1","first-page":"1","volume-title":"White Paper: Precision Medicine for Newborns by 26\u2010Hour Whole Genome Sequencin","author":"Genome Edico","year":"2017"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00139-3"},{"key":"e_1_2_8_11_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41525-018-0045-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.111"},{"key":"e_1_2_8_13_1","unstructured":"Ibid. Friedmanet\u00a0al. Genomic Newborn Screening;"},{"key":"e_1_2_8_13_2","doi-asserted-by":"crossref","first-page":"a023150","DOI":"10.1101\/cshperspect.a023150","article-title":"Potential Uses and Inherent Challenges of Using Genome\u2010Scale Sequencing to Augment Current Newborn Screening","volume":"5","author":"Berg J. S.","year":"2015","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"key":"e_1_2_8_14_1","unstructured":"Friedmanet\u00a0al. Genomic Newborn Screening;"},{"key":"e_1_2_8_14_2","article-title":"Surprisingly Few New Parents Enlist in Study to Have Baby's Genome Sequenced","author":"Kaiser J.","year":"2016","journal-title":"Science Magazine"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022146510386794"},{"key":"e_1_2_8_16_1","first-page":"6","author":"Botkin","journal-title":"Points to Consider"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-0624"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hast.876"},{"key":"e_1_2_8_19_1","author":"Friedman","journal-title":"Genomic Newborn Screening"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0002"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2006.08.009"},{"key":"e_1_2_8_20_3","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-014-9712-9"},{"key":"e_1_2_8_21_1","unstructured":"McCulloughet\u00a0al. Professionally Responsible Disclosure;"},{"key":"e_1_2_8_21_2","first-page":"2146","article-title":"Genomic Sequencing in Newborn Screening Programs","volume":"307","author":"Dondorp W. J.","year":"2012","journal-title":"Journal of the American Medical Association"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hast.877"},{"key":"e_1_2_8_23_1","author":"Friedman","journal-title":"Genomic Newborn Screening"},{"key":"e_1_2_8_24_1","unstructured":"Ibid."},{"key":"e_1_2_8_25_1","unstructured":"National Human Genome Research Institute The Human Genome Project Completion: Frequently Asked Questions https:\/\/www.genome.gov\/11006943\/human-genome-project-completion-frequently-asked-questions\/."},{"key":"e_1_2_8_26_1","unstructured":"Ibid."},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0021860"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/35052579"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra012577"},{"key":"e_1_2_8_28_3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7132.693"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.24.2985"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.7326\/M17-0188"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr349"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9566.12460"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3182088158"},{"key":"e_1_2_8_34_1","unstructured":"Williget\u00a0al. Whole\u2010Genome Sequencing for Identification;"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.150823"},{"key":"e_1_2_8_34_3","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.58"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.14601"},{"key":"e_1_2_8_36_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1159\/000371398","article-title":"Genomic Sequencing and the Impact of Molecular Diagnosis on Patient Care","volume":"6","author":"Solomon B. D.","year":"2015","journal-title":"Molecular Syndromology"},{"key":"e_1_2_8_37_1","unstructured":"Iglesiaset\u00a0al. Usefulness of Whole\u2010Exome Sequencing."},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-2252"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hast.878"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2011.78"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hast.879"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.803"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41525-018-0049-4"},{"key":"e_1_2_8_44_1","unstructured":"BieseckerandGreen Diagnostic Clinical Genome and Exome Sequencing 2423."},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.14665"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2012.176"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/hast.880"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2012.113"},{"key":"e_1_2_8_49_1","unstructured":"TimmermansandBuchbinder Patients\u2010in\u2010Waiting;"},{"key":"e_1_2_8_49_2","unstructured":"Berget\u00a0al. Newborn Sequencing in Genomic Medicine and Public Health."},{"key":"e_1_2_8_50_1","doi-asserted-by":"crossref","DOI":"10.1353\/book.27241","volume-title":"The PKU Paradox: A Short History of a Genetic Disease","author":"Paul D. B.","year":"2013"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2015.03.002"},{"key":"e_1_2_8_52_1","unstructured":"Centers for Disease Control and Prevention Newborn Screening and Improved Outcomes CDC Grand Rounds: Morbidity and Mortality Weekly Report61 no. 21 (2012):390\u201093."},{"key":"e_1_2_8_53_1","volume-title":"Principles and Practice of Screening for Disease","author":"Wilson J. M.","year":"1968"},{"key":"e_1_2_8_54_1","first-page":"12S","article-title":"Newborn Screening: Toward a Uniform Screening Panel and System","volume":"8","author":"Advisory Committee on Heritable Disorders in Newborns and Children","year":"2006","journal-title":"Genetics in Medicine"},{"key":"e_1_2_8_54_2","unstructured":"U.S. Department of Health and Human Services Advisory Committee on Heritable Disorders in Newborns and Children Recommended Uniform Screening Panel 2018."},{"key":"e_1_2_8_55_1","volume":"27","author":"Wilson","journal-title":"Principles and Practice of Screening for Disease"},{"key":"e_1_2_8_56_1","unstructured":"Friedmanet\u00a0al. Genomic Newborn Screening;"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.07.050112"},{"key":"e_1_2_8_57_1","author":"Paul","journal-title":"The PKU Paradox"},{"key":"e_1_2_8_58_1","first-page":"7","article-title":"Universal State Newborn Screening Programs Can Reduce Health Disparities","volume":"169","author":"Brosco J. P.","year":"2015","journal-title":"Journal of the American Medical Association Pediatrics"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.68"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1353\/hcr.0.0009"},{"key":"e_1_2_8_60_1","unstructured":"GoldenbergandSharp Ethical Hazards;"},{"key":"e_1_2_8_60_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-720X.2010.00522.x"},{"key":"e_1_2_8_60_3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2547"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/00125817-200007000-00011"},{"key":"e_1_2_8_62_1","volume-title":"The Changing Moral Focus of Newborn Screening: An Ethical Analysis by the President's Council on Bioethics","author":"The President's Council on Bioethics","year":"2008"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/hast.881"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-2725-4_18"},{"key":"e_1_2_8_64_2","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195111187.001.0001","volume-title":"Beginnings Count: The Technological Imperative in American Health Care","author":"Rothman D. J.","year":"1997"},{"key":"e_1_2_8_64_3","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181a9d66c"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-090711-163741"},{"key":"e_1_2_8_66_1","author":"Friedman","journal-title":"Genomic Newborn Screening"},{"key":"e_1_2_8_66_2","unstructured":"GoldenbergandSharp Ethical Hazards."},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2572"},{"issue":"2011","key":"e_1_2_8_67_2","first-page":"703","article-title":"State Laws Regarding the Retention and Use of Residual Newborn Screening Blood Samples","volume":"127","author":"Lewis M. H.","journal-title":"Pediatrics"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/hast.882"},{"key":"e_1_2_8_69_1","doi-asserted-by":"crossref","unstructured":"TariniandGoldenberg Ethical Issues with Newborn Screening in the Genomics Era 381\u201093.","DOI":"10.1146\/annurev-genom-090711-163741"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-0811"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/hast.883"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.09.066"},{"key":"e_1_2_8_73_1","first-page":"S111","article-title":"Health Facts for You: CFTR\u2010Related Metabolic Syndrome (CRMS)","volume":"155","author":"Health UW","year":"2009","journal-title":"Journal of Pediatrics"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.76"},{"key":"e_1_2_8_74_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40142-016-0084-3"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3731D"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/hast.884"},{"key":"e_1_2_8_77_1","unstructured":"GoldenbergandSharp Ethical Hazards;"},{"key":"e_1_2_8_77_2","doi-asserted-by":"publisher","DOI":"10.1525\/jer.2007.2.3.3"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/hast.66"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2017.1624"},{"key":"e_1_2_8_80_1","volume-title":"The Medicalization of Society: On the Transformation of Human Conditions into Treatable Disorders","author":"Conrad P.","year":"2008"},{"key":"e_1_2_8_81_1","unstructured":"Jeungstet\u00a0al. Personalized to Precision Medicine;"},{"key":"e_1_2_8_81_2","doi-asserted-by":"publisher","DOI":"10.1136\/medethics-2014-102026"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atg.2016.01.008"},{"key":"e_1_2_8_82_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2012-101207"},{"key":"e_1_2_8_82_3","doi-asserted-by":"publisher","DOI":"10.1007\/s12687-017-0325-5"},{"key":"e_1_2_8_82_4","doi-asserted-by":"publisher","DOI":"10.1159\/000455006"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/505286a"},{"key":"e_1_2_8_84_1","unstructured":"Food and Drug Administration FDA Allows Marketing of First Direct\u2010to\u2010Consumer Tests That Provide Genetic Risk Information for Certain Conditions FDA News Release April 6 2017 https:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm551185.htm."},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2017.11.001"},{"key":"e_1_2_8_86_1","article-title":"20 Key Players in the Direct\u2010to\u2010Consumer Lab Testing Market","author":"Kaeshavan M.","year":"2016","journal-title":"MedCity News"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-009-9253-9"},{"key":"e_1_2_8_88_1","article-title":"Test Your DNA for Diseases\u2014No Doctor Required","author":"Rochman B.","year":"2012","journal-title":"TIME"},{"key":"e_1_2_8_89_1","volume":"241","author":"Ross","journal-title":"Technical Report"},{"key":"e_1_2_8_90_1","volume-title":"Risk Society: Towards a New Modernity","author":"Beck U.","year":"1992"},{"key":"e_1_2_8_91_1","unstructured":"Blosset\u00a0al. Impact of Direct\u2010to\u2010Consumer Genomic Testing;"},{"key":"e_1_2_8_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.34"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-017-0106-7"},{"key":"e_1_2_8_93_1","unstructured":"Blosset\u00a0al. Impact of Direct\u2010to\u2010Consumer Genomic Testing;"},{"key":"e_1_2_8_93_2","unstructured":"Koelleret\u00a0al. Utilization of Genetic Counseling;"},{"key":"e_1_2_8_93_3","doi-asserted-by":"publisher","DOI":"10.7326\/M15-0995"},{"key":"e_1_2_8_94_1","first-page":"408","author":"Timmermans","journal-title":"Patients\u2010in\u2010Waiting"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2018.0344"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2013.73"},{"key":"e_1_2_8_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.190"},{"key":"e_1_2_8_97_1","unstructured":"Botkinet\u00a0al. Points to Consider;"},{"key":"e_1_2_8_97_2","unstructured":"Rosset\u00a0al. Technical Report;"},{"key":"e_1_2_8_97_3","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2011.94"},{"key":"e_1_2_8_97_4","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.129"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-011-9474-6"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/hast.885"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/hast.886"}],"container-title":["Hastings Center Report"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhast.874","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hast.874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T06:45:31Z","timestamp":1720507531000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hast.874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":137,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1002\/hast.874"],"URL":"https:\/\/doi.org\/10.1002\/hast.874","archive":["Portico"],"relation":{},"ISSN":["0093-0334","1552-146X"],"issn-type":[{"value":"0093-0334","type":"print"},{"value":"1552-146X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"2018-08-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}