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The activation pattern may be a function of the behavioral context of the movement rather than of its mechanical properties. We compare motor system activation patterns associated with isolated single\u2010joint movement of corresponding joints in arm and leg carried out in equal frequency and range. Eleven healthy volunteers underwent BOLD\u2010weighted fMRI while performing repetitive elbow or knee extension\/flexion. To relate elbow and knee activation to the well\u2010described patterns of finger movement, serial finger\u2010to\u2010thumb opposition was assessed in addition. After identifying task\u2010related voxels using statistical parametric mapping, activation was measured in five regions of interest (ROI; primary motor [M1] and somatosensory cortex [S1], premotor cortex, supplementary motor area [SMA] divided into preSMA and SMA\u2010proper, and cerebellum). Differences in the degree of activation across ROIs were found between elbow and knee movement. SMA\u2010proper activation was prominent for knee, but almost absent for elbow movement (<jats:italic>P<\/jats:italic> &lt; 0.05); finger movement produced small but constant SMA\u2010proper activation. Ipsilateral M1 activation was detected during knee and finger movement, but was absent for the elbow task (<jats:italic>P<\/jats:italic> &lt; 0.05). Knee movement showed less lateralization in M1 and S1 than other tasks (<jats:italic>P<\/jats:italic> &lt; 0.05). The data demonstrate that central motor structures contribute differently to isolated elbow and knee movement. Activation during knee movement shows similarities to gait\u2010related activation patterns. Hum. Brain Mapping 17:131\u2013140, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hbm.10058","type":"journal-article","created":{"date-parts":[[2002,10,9]],"date-time":"2002-10-09T04:27:46Z","timestamp":1034137666000},"page":"131-140","source":"Crossref","is-referenced-by-count":165,"title":["Comparing brain activation associated with isolated upper and lower limb movement across corresponding joints"],"prefix":"10.1002","volume":"17","author":[{"given":"Andreas R.","family":"Luft","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald V.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Forrester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Whitall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard 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