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The purpose of the present study was to demonstrate the consequences of atypical chiasmatic crossing with monocular visual stimulation using functional magnetic resonance imaging (fMRI). Sixteen patients with albinism and fifteen normally pigmented controls were stimulated with a monocular visual activation paradigm using flickering checkerboards. In patients, we observed contralaterally dominated activation of visual cortices correlating to clinical albinism parameters. This confirms albinism as a continuous range of hypopigmentation disorders. Additionally, albinos showed activation of the superior colliculus and of visual motion areas although the stimulus was stationary. Activation of visual motion areas is due probably to congenital nystagmus without a conscious correlate like oscillopsia. Hum. Brain Mapping 23:40\u201352, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hbm.20046","type":"journal-article","created":{"date-parts":[[2004,6,15]],"date-time":"2004-06-15T17:57:52Z","timestamp":1087322272000},"page":"40-52","source":"Crossref","is-referenced-by-count":32,"title":["Monocular visual activation patterns in albinism as revealed by functional magnetic resonance imaging"],"prefix":"10.1002","volume":"23","author":[{"given":"Bernd","family":"Schmitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"K\u00e4smann\u2010Kellner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph M.","family":"Krick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Gr\u00f6n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Backens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Reith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,6,14]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"339","article-title":"Oscillopsia and tolerance to retinal image movement in congenital nystagmus","volume":"40","author":"Abadi RW","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0746"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(83)90162-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/116.6.1293"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-199812000-00007"},{"key":"e_1_2_7_7_1","volume-title":"Vergleichende Lokalisationslehre der Gro\u00dfhirnrinde","author":"Brodmann K","year":"1909"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.7.1281"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/108.1.1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1985.0021"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198606193142508"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0590"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02080368"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002210050356"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1523\/JNEUROSCI.09-07-02353.1989","article-title":"Nasotemporal overlap of crossed and uncrossed retinal ganglion cell projections in the Japanese monkey (Macaca fuscata)","volume":"9","author":"Fukuda Y","year":"1989","journal-title":"J Neurosci"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(01)00069-4"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S095252380118209X"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/73980"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(71)90121-1"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0574-44"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1996.49"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90750-7"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.10.1921"},{"key":"e_1_2_7_24_1","first-page":"480","article-title":"Statistical modelling of low\u2010frequency confounds in fMRI","volume":"5","author":"Holmes AP","year":"1997","journal-title":"Neuroimage"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1968.sp008455"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1971.sp009603"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990315)405:3<394::AID-CNE9>3.0.CO;2-Y"},{"key":"e_1_2_7_28_1","first-page":"340","article-title":"Exploration of retro\u2010chiasmatic visual pathways in human albinism","volume":"23","author":"Jarry D","year":"2000","journal-title":"J Fr Ophthalmol"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.4.1393"},{"key":"e_1_2_7_30_1","first-page":"189","volume":"20","author":"K\u00e4smann\u2010Kellner B","year":"1999","journal-title":"Albinismus: Klassifikation und klinisches Spektrum Z prakt Augenheilkd"},{"key":"e_1_2_7_31_1","unstructured":"KirkDL(1976):Projections of the visual field by the axons of cat retinal ganglion cells. 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