{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:21:17Z","timestamp":1775150477906,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,6,9]],"date-time":"2006-06-09T00:00:00Z","timestamp":1149811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multiple chemical sensitivity (MCS) is characterized by somatic distress upon exposure to odors. As in other idiopathic environmental intolerances, the mechanisms behind the reported hypersensitivity are unknown. Using the advantage of the well\u2010defined trigger (odor), we investigated whether subjects with MCS could have an increased odor\u2010signal response in the odor\u2010processing neuronal circuits. Positron emission tomography (PET) activation studies with several different odorants were carried out in 12 MCS females and 12 female controls. Activation was defined as a significant increase in regional cerebral blood flow (rCBF) during smelling of the respective odorant compared to smelling of odorless air. The study also included online measurements of respiratory frequency and amplitude and heart rate variations by recording of R wave intervals (RR) on the surface electrocardiogram. The MCS subjects activated odor\u2010processing brain regions <jats:italic>less<\/jats:italic> than controls, despite the reported, and physiologically indicated (decreased RR interval) distress. In parallel, they showed an odorant\u2010related increase in activation of the anterior cingulate cortex and cuneus\u2010precuneus. Notably, the baseline rCBF was normal. Thus, the abnormal patterns were observed only in response to odor signals. Subjects with MCS process odors differently from controls, however, without signs of neuronal sensitization. One possible explanation for the observed pattern of activation in MCS is a top\u2010down regulation of odor\u2010response via cingulate cortex. Hum. Brain Mapp, 2007. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hbm.20266","type":"journal-article","created":{"date-parts":[[2006,6,9]],"date-time":"2006-06-09T20:01:02Z","timestamp":1149883262000},"page":"172-182","source":"Crossref","is-referenced-by-count":83,"title":["Odor processing in multiple chemical 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