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Furthermore, recent resting\u2010state functional magnetic resonance imaging (fMRI) studies have also shown that low\u2010frequency (&lt;0.08 Hz) fluctuations (LFF) of the blood oxygenation level\u2010dependent signals were abnormal in several brain areas of AD patients. However, few studies have investigated disturbed LFF connectivity in AD patients. By using resting\u2010state fMRI, this study sought to investigate the abnormal functional connectivities throughout the entire brain of early AD patients, and analyze the global distribution of these abnormalities. For this purpose, the authors divided the whole brain into 116 regions and identified abnormal connectivities by comparing the correlation coefficients of each pair. Compared with healthy controls, AD patients had decreased positive correlations between the prefrontal and parietal lobes, but increased positive correlations within the prefrontal lobe, parietal lobe, and occipital lobe. The AD patients also had decreased negative correlations (closer to zero) between two intrinsically anti\u2010correlated networks that had previously been found in the resting brain. By using resting\u2010state fMRI, our results supported previous studies that have reported an anterior\u2013posterior disconnection phenomenon and increased within\u2010lobe functional connectivity in AD patients. In addition, the results also suggest that AD may disturb the correlation\/anti\u2010correlation effect in the two intrinsically anti\u2010correlated networks. Hum Brain Mapp 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hbm.20324","type":"journal-article","created":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T15:00:15Z","timestamp":1164726015000},"page":"967-978","source":"Crossref","is-referenced-by-count":632,"title":["Altered functional connectivity in early Alzheimer's disease: A resting\u2010state fMRI 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