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We used magnetoencephalography to investigate the pattern of prefrontal and parieto\u2010occipital alpha modulation related to two variants of visual working memory task (delayed matching\u2010to\u2010sample) with and without a distractor. We tested nonmedicated, nondepressed patients suffering obsessive\u2010compulsive disorder (OCD), and pair\u2010matched healthy controls. The level of event\u2010related alpha as a function of time was estimated using the temporal\u2010spectral evolution technique. The results in OCD patients indicated: (1) a lower level of prestimulus (reference) alpha when compared to controls, (2) a task\u2010phase specific reduction in event\u2010related alpha ERD in particular for delayed matching\u2010to\u2010sample task with distractor, (3) no significant correlations between the pattern of modulation in prefrontal and parietal\u2010occipital alpha oscillatory activity. Despite showing an abnormally low alpha modulation, the OCD patients' performance accuracy was normal. The results suggest a relationship of alpha oscillations and the underlying thalamocortical network to etiology of OCD and an involvement of a compensatory mechanism related to effortful inhibition of extrinsic and intrinsic interference. 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