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Here we tested the hypothesis that directionality of fronto\u2010parietal functional coupling of electroencephalographic (EEG) rhythms is relatively preserved in amnesic MCI subjects in whom the cognitive decline is mainly explained by white\u2010matter vascular load. Resting EEG was recorded in 40 healthy elderly (Nold) and 78 amnesic MCI. In the MCI subjects, white\u2010matter vascular load was quantified based on magnetic resonance images (0\u201330 visual rating scale). EEG rhythms of interest were \u03b4 (2\u20134 Hz), \u03b8 (4\u20138 Hz), \u03b11 (8\u201310.5 Hz), \u03b12 (10.5\u201313 Hz), \u03b21 (13\u201320 Hz), and \u03b22 (20\u201330 Hz). Directionality of fronto\u2010parietal functional coupling of EEG rhythms was estimated by directed transfer function software. As main results, (i) fronto\u2010parietal functional coupling of EEG rhythms was higher in magnitude in the Nold than in the MCI subjects; (ii) more interestingly, that coupling was higher at \u03b8, \u03b11, \u03b12, and \u03b21 in MCI V+ (high vascular load;<jats:italic>N<\/jats:italic>= 42; MMSE = 26) than in MCI V\u2212 group (low vascular load;<jats:italic>N<\/jats:italic>= 36; MMSE= 26.7). These results are interpreted as supporting the additive model according to which MCI state would result from the combination of cerebrovascular and neurodegenerative lesions. Hum Brain Mapp 2008. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hbm.20467","type":"journal-article","created":{"date-parts":[[2007,11,2]],"date-time":"2007-11-02T16:20:37Z","timestamp":1194020437000},"page":"1355-1367","source":"Crossref","is-referenced-by-count":50,"title":["White matter vascular lesions are related to parietal\u2010to\u2010frontal coupling of EEG rhythms in mild cognitive impairment"],"prefix":"10.1002","volume":"29","author":[{"given":"Claudio","family":"Babiloni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni 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