{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T12:53:42Z","timestamp":1769950422748,"version":"3.49.0"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,1,2]],"date-time":"2008-01-02T00:00:00Z","timestamp":1199232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous functional neuroimaging studies on executive function suggested multiple functionally aberrant cortical regions in patients with Huntington's disease (HD). However, little is known about the neural mechanisms of working memory (WM) function in this patient population. The objective of this study was to investigate the functional neuroanatomy of WM in HD patients. We used event\u2010related functional magnetic resonance imaging and a parametric verbal WM task to investigate cerebral function during WM performance in 16 healthy control subjects and 12 mild to moderate stage HD patients. We excluded incorrectly performed trials to control for potential accuracy\u2010related activation confounds. Voxel\u2010based morphometry (VBM) was used to control for confounding cortical and subcortical atrophy. We found that HD patients were slower and less accurate than healthy controls across all WM load levels. In addition, HD patients showed lower activation in the left dorso\u2010 and ventrolateral prefrontal cortex, the left inferior parietal cortex, the left putamen, and the right cerebellum at high WM load levels only. VBM revealed gray matter differences in the bilateral caudate nucleus and the thalamus, as well as in inferior parietal and right lateral prefrontal regions. However, volumetric abnormalities in the patient group did not affect the activation differences obtained during WM task performance. These findings demonstrate that WM\u2010related functional abnormalities in HD patients involve distinct WM network nodes associated with cognitive control and subvocal rehearsal. Moreover, aberrant cortical function in HD patients may occur in brain regions, which are relatively well preserved in terms of brain atrophy. Hum Brain Mapp, 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hbm.20502","type":"journal-article","created":{"date-parts":[[2008,1,2]],"date-time":"2008-01-02T16:16:56Z","timestamp":1199290616000},"page":"327-339","source":"Crossref","is-referenced-by-count":74,"title":["Cortical dysfunction in patients with Huntington's disease during working memory performance"],"prefix":"10.1002","volume":"30","author":[{"given":"Robert C.","family":"Wolf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nenad","family":"Vasic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Sch\u00f6nfeldt\u2010Lecuona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Ecker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg Bernhard","family":"Landwehrmeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.09.030186.002041"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2007.02.018"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0582"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.2.394"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(00)01538-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1201"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14734220701286195"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(86)90039-1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1978.00500330033006"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200204160-00033"},{"key":"e_1_2_6_12_1","first-page":"773","article-title":"Altered patterns of regional cerebral blood flow in patients with Huntington's disease: A SPECT study during rest and cognitive or motor activation","volume":"41","author":"Deckel AW","year":"2000","journal-title":"J Nucl Med"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002210000395"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-6792-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20684"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80018-5"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.460020402"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1995.1007"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1990.00530040062020"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1996.0129"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0786"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.11.1018"},{"key":"e_1_2_6_23_1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S1053-8119(18)31587-8","article-title":"Generalisability, random effects and population inference","volume":"4","author":"Holmes AP","year":"1998","journal-title":"NeuroImage"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110204"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.14.8410"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1999.0475"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh185"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2004.03.002"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/113.5.1405"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.58.5.598"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.5.1633"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0461-9"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-15-06351.2003"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03108.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-6080(00)00058-7"},{"key":"e_1_2_6_36_1","first-page":"21","article-title":"Brain imaging and cognitive dysfunctions in Huntington's disease","volume":"31","author":"Montoya A","year":"2006","journal-title":"J Psychiatry Neurosci"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.13.3.342"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(76)80035-4"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(71)90067-4"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(199501)51:1<48::AID-JCLP2270510109>3.0.CO;2-E"},{"key":"e_1_2_6_41_1","first-page":"1715","article-title":"fMRI biomarker of early neuronal dysfunction in presymptomatic Huntington's disease","volume":"25","author":"Paulsen JS","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg119"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.12.3.414"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1602\/neurorx.1.2.263"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20979"},{"key":"e_1_2_6_46_1","article-title":"Longitudinal analysis of regional gray matter loss in Huntington disease: Effects of the length of the expanded CAg repeat","author":"Ruocco HH","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.11.6558"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1162\/08989290260138627"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.29.1.1"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617701711046"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(01)00060-0"},{"key":"e_1_2_6_52_1","volume-title":"Co\u2010Planar Stereotaxic Atlas of the Human Brain","author":"Talairach J","year":"1988"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.098368"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.07.009"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.01.041"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617706060565"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1996.0135"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.1.94"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2006.05.015"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2006.12.001"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm210"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2005.06.002"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.20.4.565.1468"},{"key":"e_1_2_6_64_1","volume-title":"Testbatterie zur Aufmerksamkeitspr\u00fcfung (TAP)","author":"Zimmermann P","year":"1994"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.20502","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.20502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T05:12:53Z","timestamp":1695964373000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.20502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,2]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1002\/hbm.20502"],"URL":"https:\/\/doi.org\/10.1002\/hbm.20502","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,2]]}}}