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In the present study, we therefore investigated the cortical topography of volitional swallowing in patients with X\u2010linked bulbospinal neuronopathy (Kennedy disease, KD). Eight dysphagic patients with genetically proven KD and an age\u2010matched healthy control group were studied by means of whole\u2010head magnetoencephalography using a previously established swallowing paradigm. Analysis of data was carried out with synthetic aperture magnetometry (SAM). The group analysis of individual SAM results was performed using a permutation test. KD patients showed significantly larger swallow\u2010related activation of the bilateral primary sensorimotor cortex than healthy controls. In contrast to the control group, in KD patients the maximum activity was located in the right sensorimotor cortex. Furthermore, while in nondysphagic subjects a previously described time\u2010dependent shift from the left to the right hemisphere was found during the one second of most pronounced swallow\u2010related muscle activity, KD patients showed a strong right hemispheric activation in each time segment analyzed. Since the right hemisphere has an established role in the coordination of the pharyngeal phase of swallowing, the stronger right hemispheric activation observed in KD patients indicates cortical compensation of pharyngeal phase dysphagia. Hum Brain Mapp 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hbm.20603","type":"journal-article","created":{"date-parts":[[2008,6,11]],"date-time":"2008-06-11T19:46:30Z","timestamp":1213213590000},"page":"1352-1360","source":"Crossref","is-referenced-by-count":32,"title":["Cortical compensation associated with dysphagia caused by selective degeneration of bulbar motor neurons"],"prefix":"10.1002","volume":"30","author":[{"given":"Rainer","family":"Dziewas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga 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