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The procedure is demonstrated in three patients suffering from aperceptive tactile agnosia of the right hand due to chronic infarction of the left parietal cortex. Patient 1 presents a lesion in areas of the postcentral sulcus, Patient 3 in areas of the superior parietal lobule and adjacent intraparietal sulcus, and Patient 2 lesions in both regions. On the basis of neurobehavioral data, we conjectured degradation of sequential elementary sensory information processing within the postcentral gyrus, impeding texture recognition in Patients 1 and 2, and disturbed kinaesthetic information processing in the posterior parietal lobe, causing degraded shape recognition in the patients 2 and 3. The involvement of Brodmann areas 4a, 4p, 3a, 3b, 1, 2, and areas IP1 and IP2 of the intraparietal sulcus was assessed in terms of the voxel overlap between the spatially transformed lesion masks and the 50%\u2010isocontours of the cytoarchitectonic maps. The disruption of the critical cytoarchitectonic areas and the impaired subfunctions, texture and shape recognition, relate as conjectured above. We conclude that the proposed method represents a promising approach to hypothesis\u2010driven lesion analyses, yielding lesion\u2010function correlates based on a cytoarchitectonic model. Finally, the lesion\u2010function correlates are validated by functional imaging reference data. Hum Brain Mapp 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hbm.20617","type":"journal-article","created":{"date-parts":[[2008,7,17]],"date-time":"2008-07-17T18:32:50Z","timestamp":1216319570000},"page":"1444-1456","source":"Crossref","is-referenced-by-count":34,"title":["Analysis of lesions in patients with unilateral tactile agnosia using cytoarchitectonic probabilistic maps"],"prefix":"10.1002","volume":"30","author":[{"given":"Lars","family":"H\u00f6mke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Amunts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz","family":"B\u00f6nig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Fretz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinand","family":"Binkofski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Zilles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Weder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,17]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"151","volume-title":"Anatomic Basis of Functional MR Imaging","author":"Amunts K","year":"2001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1999.0516"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1145\/344779.344972"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00753.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.1.132"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0140525X07001409"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00362-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.460030307"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf245"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0845"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.4.762"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000036083.90045.08"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1137\/S0036139900368844"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20849"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0140525X07001392"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.172.3980.273"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhi106"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(200004)9:4<192::AID-HBM2>3.0.CO;2-Y"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/382805a0"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0548"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0858"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","unstructured":"HennS H\u00f6mkeL WitschK(2004): Lesion Preserving Image Registration with Applications to Human Brains. 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