{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:50:30Z","timestamp":1790927430464,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,4,11]],"date-time":"2011-04-11T00:00:00Z","timestamp":1302480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pramipexole is widely prescribed to treat Parkinson's disease. It has been found to cause impulse control disorders such as pathological gambling. To examine how pramipexole modulates the network of reward anticipation, we carried out a pharmacological functional magnetic resonance imaging study with a double\u2010blind, within\u2010subject design. During the anticipation of monetary rewards, pramipexole increased the activity of the nucleus accumbens (NAcc), enhanced the interaction between the NAcc and the anterior insula, but weakened the interaction between the NAcc and the prefrontal cortex. These results suggest that pramipexole may exaggerate incentive and affective responses to possible rewards, but reduce the top\u2010down control of impulses, leading to an increase in impulsive behaviors. This imbalance between the prefrontal\u2010striatum connectivity and the insula\u2010striatum connectivity may represent the neural mechanism of pathological gambling caused by pramipexole. Hum Brain Mapp, 2011. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hbm.21067","type":"journal-article","created":{"date-parts":[[2010,6,9]],"date-time":"2010-06-09T10:01:46Z","timestamp":1276077706000},"page":"800-811","source":"Crossref","is-referenced-by-count":82,"title":["Pramipexole modulates the neural network of reward anticipation"],"prefix":"10.1002","volume":"32","author":[{"given":"Zheng","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estela","family":"Camara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"M\u00fcnte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0690-y"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.02.018"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1584"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00307-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002139900345"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300542"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4862-03.2004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.12.050"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.09.019.2008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dr.2007.08.003"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2228"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-004-0172-5"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.9.noc50009"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1996.6379"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291705005891"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2007.09.002"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2431-05.2005"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1062-06.2006"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(99)00049-1"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.03.020"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0686-7"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2008.0155"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0593"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-16-j0002.2001"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.06.030"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.08.008"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-5846(91)90058-9"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200109000-00002"},{"key":"e_1_2_6_30_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/01.WCB.0000048520.34839.1A","article-title":"Imaging human mesolimbic dopamine transmission with positron emission tomography. II. Amphetamine\u2010induced dopamine release in the functional subdivisions of the striatum","volume":"23","author":"Martinez D","year":"2003","journal-title":"J Cereb Blood Flow Metab"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1100907"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00603-7"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/39051"},{"key":"e_1_2_6_34_1","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/S0022-3565(25)12192-7","article-title":"Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907","volume":"275","author":"Pugsley TA","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1378"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002479"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.06.035"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1894"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-16-05916.2001"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2058-08.2008"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.09.044"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsn051"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm120"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp078"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.7.969"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.21067","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.21067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:11:31Z","timestamp":1740150691000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.21067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,11]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["10.1002\/hbm.21067"],"URL":"https:\/\/doi.org\/10.1002\/hbm.21067","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,11]]}}}