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This study investigated the neural correlates of stress and alcohol context cue experiences and examined sex differences in these responses. Using functional magnetic resonance imaging, brain responses were examined while 43 right\u2010handed, socially drinking, healthy individuals (23 females) engaged in brief guided imagery of personalized stress, alcohol\u2010cue, and neutral\u2010relaxing scenarios. Stress and alcohol\u2010cue exposure increased activity in the cortico\u2013limbic\u2013striatal circuit (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01, corrected), encompassing the medial prefrontal cortex (mPFC), orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), left anterior insula, striatum, and visuomotor regions (parietal and occipital lobe, and cerebellum). Activity in the left dorsal striatum increased during stress, while bilateral ventral striatum activity was evident during alcohol\u2010cue exposure. Men displayed greater stress\u2010related activations in the mPFC, rostral ACC, posterior insula, amygdala, and hippocampus than women, whereas women showed greater alcohol\u2010cue\u2010related activity in the superior and middle frontal gyrus (SFG\/MFG) than men. Stress\u2010induced anxiety was positively associated with activity in emotion\u2010modulation regions, including the medial OFC, ventromedial PFC, left superior\u2010mPFC, and rostral ACC in men, but in women with activation in the SFG\/MFG, regions involved in cognitive processing. Alcohol craving was significantly associated with the striatum (encompassing dorsal, and ventral) in men, supporting its involvement in alcohol \u201curge\u201d in healthy men. These results indicate sex differences in neural processing of stress and alcohol\u2010cue experiences and have implications for sex\u2010specific vulnerabilities to stress\u2010 and alcohol\u2010related psychiatric disorders. Hum Brain Mapp, 2011. \u00a9 2010 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/hbm.21165","type":"journal-article","created":{"date-parts":[[2010,12,15]],"date-time":"2010-12-15T12:41:05Z","timestamp":1292416865000},"page":"1998-2013","source":"Crossref","is-referenced-by-count":184,"title":["Sex differences in neural responses to stress and alcohol context cues"],"prefix":"10.1002","volume":"32","author":[{"given":"Dongju","family":"Seo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiru","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl M.","family":"Lacadie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen A.","family":"Tsou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keri","family":"Bergquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajita","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000288097"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/01461672002611001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3565-07.2007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2005.05.035"},{"key":"e_1_2_7_6_1","first-page":"447","volume-title":"Handbook of Emotions. .","author":"Brody LR","year":"1993"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1162\/08989290051137585"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.76.5.839"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327957PSPR0504_4"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2008.00679.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1080\/01621459.1972.10481273","article-title":"Estimates of parameters of a censored regression sample","volume":"67","author":"Chen EH","year":"1972","journal-title":"J Am Stat Assoc"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.14.1685"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbmr.1996.0014"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5479.591"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agh176"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171203"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1214\/aoms\/1177705900"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.027"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/14659890500419717"},{"key":"e_1_2_7_20_1","doi-asserted-by":"crossref","unstructured":"EvansA CollinsD MillsS BrownE KellyR PetersT(1993):3D statistical neuroanatomical models from 305 MRI volumes. 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