{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:03:31Z","timestamp":1773155011559,"version":"3.50.1"},"reference-count":69,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,1,21]],"date-time":"2011-01-21T00:00:00Z","timestamp":1295568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tourette's syndrome (TS) is a developmental neuropsychiatric disorder characterized by motor and vocal tics as well as psychiatric comorbidities. Disturbances of the fronto\u2010striatal\u2010thalamic pathways responsible for motor control and impulse inhibition have been previously described in other studies. Although differences in motor performance are well recognized, imaging data elucidating the neuronal correlates are scarce. Here, we examined 19 adult TS patients (13 men, aged 22\u201352 years, mean = 34.3 years) and 18 age\u2010 and sex\u2010matched controls (13 men, aged 24\u201357 years, mean = 37.6 years) in a functional magnetic resonance imaging study at 1.5 T. We corrected for possible confounds introduced by tics, motion, and brain\u2010structural differences as well as age, sex, comorbidities, and medication. Patients and controls were asked to perform a sequential finger\u2010tapping task using their right, left, and both hands, respectively. Task performance was monitored by simultaneous MR\u2010compatible video recording. Although behavioral data obtained during scanning did not show significant differences across groups, we observed differential neuronal activation patterns depending on both handedness (dominant vs. nondominant) and tapping frequency in frontal, parietal, and subcortical areas. When controlling for open motor performance, a failure of deactivation in easier task conditions was found in the subgenual cingulate cortex in the TS patients. In addition, performance\u2010related functional connectivity of lower\u2010 and higher\u2010order motor networks differed between patients and controls. In summary, although open performance was comparable, patients showed different neuronal networks and connectivity patterns when performing increasingly demanding tasks, further illustrating the impact of the disease on the motor system. Hum Brain Mapp, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hbm.21175","type":"journal-article","created":{"date-parts":[[2011,1,21]],"date-time":"2011-01-21T14:46:50Z","timestamp":1295621210000},"page":"2014-2026","source":"Crossref","is-referenced-by-count":27,"title":["Altered motor network activation and functional connectivity in adult tourette's syndrome"],"prefix":"10.1002","volume":"32","author":[{"given":"Cornelius 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