{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:13:15Z","timestamp":1791353595624,"version":"4.3.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,2,17]],"date-time":"2011-02-17T00:00:00Z","timestamp":1297900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To clarify the characteristics of interhemispheric connections, we investigated cortico\u2010cortical evoked potentials (CCEP) in human. Fourteen patients with temporal lobe epilepsy who underwent invasive EEG monitoring with bilaterally implanted subdural electrodes were studied. Electric pulse stimuli were given in a bipolar fashion at two adjacent electrodes on and around the motor area (MA) or sensory area (SA), and CCEP responses were recorded by averaging electrocorticograms from the contralateral hemisphere. Seventy\u2010two pairs of electrodes were stimulated, and 468 recordings were analyzed. Fifty\u2010one of 468 recordings demonstrated CCEP responses. Of 51 responses, 16 consisted of an initial positive triphasic wave (Type 1), 27 had an initial negative biphasic wave (Type 2), and 8 showed an initial positive biphasic wave (type 3). The mean latencies of the earliest peaks were 13.1, 28.9, and 29.4 ms in Types 1, 2, and 3 responses, respectively. The responses were more frequently evoked by stimulating facial MA (f\u2010MA) and nonfacial MA (nf\u2010MA) than by stimulating SA or noneloquent area. In both f\u2010MA and nf\u2010MA stimulation, the responses were more frequently recorded at the contralateral f\u2010MA than at the contralateral nf\u2010MA or other areas. SA stimulation never evoked CCEP responses at the contralateral MA or SA. The amplitudes were maximal when f\u2010MA was stimulated and responses recorded at the contralateral f\u2010MA. These findings suggest that the interhemispheric connections are uneven. Both f\u2010MA and nf\u2010MA send dense interhemispheric connections to the contralateral f\u2010MA. SA may have no or only rare direct connection with the contralateral MA or SA. Hum Brain Mapp, 2012. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hbm.21189","type":"journal-article","created":{"date-parts":[[2011,2,17]],"date-time":"2011-02-17T16:12:52Z","timestamp":1297959172000},"page":"14-26","source":"Crossref","is-referenced-by-count":40,"title":["Uneven interhemispheric connections between left and right primary sensori\u2010motor 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