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Previously, we investigated the motor network in children with congenital hemiparesis due to middle cerebral artery strokes (MCA, <jats:italic>n<\/jats:italic> = 6) or periventricular lesions (PL, <jats:italic>n<\/jats:italic> = 8). In the present study, we validate the use of interleaved resting\u2010state data from blocked fMRI designs to investigate the somatosensory network in these patients. The approach was validated by assessing the predicted \u201ccrossed\u2010over\u201d connectivity between the cerebral cortex and the cerebellum. Furthermore, the impact on the volume of gray\u2010matter (GM) in primary (S1) and secondary (S2) somatosensory cortex on functional connectivity measures was investigated. We were able to replicate the well\u2010known \u201ccrossed\u2010over\u201d pattern of functional connectivity between cerebral and cerebellar cortex. The MCA group displayed more sensory deficit and significantly reduced functional connectivity in the lesioned S2 (but not in lesioned S1) when compared with the PL group. However, when accounting for GM volume loss, this difference disappeared. This study demonstrates the applicability of analyzing resting\u2010state connectivity in patients with brain lesions. Reductions of functional connectivity within the somatosensory network were associated with sensory deficits, but were fully explained by the underlying GM damage. This underlines the influence of cortical GM volume on functional connectivity measures. Hum Brain Mapp, 2012. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hbm.21227","type":"journal-article","created":{"date-parts":[[2011,3,9]],"date-time":"2011-03-09T16:50:22Z","timestamp":1299689422000},"page":"628-638","source":"Crossref","is-referenced-by-count":33,"title":["Relationship between functional connectivity and sensory impairment: Red flag or red 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