{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:48:06Z","timestamp":1791179286900,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,4,11]],"date-time":"2011-04-11T00:00:00Z","timestamp":1302480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objectives:<\/jats:italic>Recent fMRI studies have shown that it is possible to reliably identify the default\u2010mode network (DMN) in the absence of any task, by resting\u2010state connectivity analyses in healthy volunteers. We here aimed to identify the DMN in the challenging patient population of disorders of consciousness encountered following coma. <jats:italic>Experimental design:<\/jats:italic> A spatial independent component analysis\u2010based methodology permitted DMN assessment, decomposing connectivity in all its different sources either neuronal or artifactual. Three different selection criteria were introduced assessing anticorrelation\u2010corrected connectivity with or without an automatic masking procedure and calculating connectivity scores encompassing both spatial and temporal properties. These three methods were validated on 10 healthy controls and applied to an independent group of 8 healthy controls and 11 severely brain\u2010damaged patients [locked\u2010in syndrome (<jats:italic>n<\/jats:italic> = 2), minimally conscious (<jats:italic>n<\/jats:italic> = 1), and vegetative state (<jats:italic>n<\/jats:italic> = 8)]. <jats:italic>Principal observations:<\/jats:italic> All vegetative patients showed fewer connections in the default\u2010mode areas, when compared with controls, contrary to locked\u2010in patients who showed near\u2010normal connectivity. In the minimally conscious\u2010state patient, only the two selection criteria considering both spatial and temporal properties were able to identify an intact right lateralized BOLD connectivity pattern, and metabolic PET data suggested its neuronal origin. <jats:italic>Conclusions:<\/jats:italic> When assessing resting\u2010state connectivity in patients with disorders of consciousness, it is important to use a methodology excluding non\u2010neuronal contributions caused by head motion, respiration, and heart rate artifacts encountered in all studied patients. Hum Brain Mapp, 2012. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hbm.21249","type":"journal-article","created":{"date-parts":[[2011,4,12]],"date-time":"2011-04-12T05:06:22Z","timestamp":1302584782000},"page":"778-796","source":"Crossref","is-referenced-by-count":131,"title":["Identifying the default\u2010mode component in spatial IC analyses of patients with disorders of consciousness"],"prefix":"10.1002","volume":"33","author":[{"given":"Andrea","family":"Soddu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Vanhaudenhuyse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Ali","family":"Bahri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Aurelie","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Boly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athena","family":"Demertzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Flory","family":"Tshibanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Stanziano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smadar","family":"Ovadia\u2010Caro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuval","family":"Nir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Maquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Papa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Malach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Laureys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Noirhomme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(05)50017-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(95)80031-X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.02.021"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2003.09.015"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2005.1634"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20577"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340409"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20602"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20672"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198505000-00002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181f697f5"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.09.017.2009"},{"key":"e_1_2_7_14_1","first-page":"8","article-title":"Advances and pitfalls in the analysis and interpretation of resting\u2010state FMRI data","volume":"4","author":"Cole DM","year":"2010","journal-title":"Front Syst Neurosci"},{"key":"e_1_2_7_15_1","first-page":"1636","article-title":"Mapping functionally related regions of brain with functional connectivity MR imaging","volume":"21","author":"Cordes D","year":"2000","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21590"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601417103"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.08.035"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.08.041"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.10.042"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2008.01.045"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800376105"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2004.10.020"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2201"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504136102"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90777.2008"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2004.02.033"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhk030"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2007.10.003"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.05.033"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1162\/0898929042568532"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0135058100"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308627101"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.071043098"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060159"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471221317"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.11.001"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600674103"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00097-1"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20813"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.12.008"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(04)00852-X"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.concog.2007.04.004"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1997.0315"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2241011005"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03160568"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(1998)6:3<160::AID-HBM5>3.0.CO;2-1"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20860"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420114"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910370407"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.09.036"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.11.018"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2177"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/218519"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2006.09.042"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1162\/089892902760191117"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20505"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.concog.2008.03.013"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905267106"},{"key":"e_1_2_7_60_1","article-title":"Resting state activity in patients with disorders of consciousness","author":"Soddu A","year":"2011","journal-title":"Funct Neurol"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405263302107"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp313"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2010.21488"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05758"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20968"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(1999)8:2\/3<151::AID-HBM13>3.0.CO;2-5"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.01.054"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.08.027"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.21249","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.21249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:18:00Z","timestamp":1696897080000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.21249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,11]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1002\/hbm.21249"],"URL":"https:\/\/doi.org\/10.1002\/hbm.21249","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,11]]}}}