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We studied nonmedicated adults with OCD and case matched healthy controls in a visual\u2010spatial working memory task with distractor. Magnetoencephalography was used to examine the medial cortex activity during anticipation of to\u2010be\u2010inhibited distractors and to\u2010be\u2010facilitated retrieval stimuli. In OCD anticipatory activation to distractors was abnormally reduced within the posterior cingulate and fusiform gyrus compared to prominent activation in controls. Conversely, OCD subjects displayed significantly increased activation to retrieval stimuli within the anterior cingulate and supplementary motor cortex. This previously unreported discordant pattern of medial anticipatory activation in OCD was accompanied by normal performance accuracy. While increased anterior cortex activation in OCD is commonly viewed as failure of inhibition, the current pattern of data implicates the operation of an anterior compensatory mechanism amending the posterior medial self\u2010regulatory networks disrupted in OCD. Hum Brain Mapp 33:2125\u20132134, 2012. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hbm.21341","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T02:34:06Z","timestamp":1314844446000},"page":"2125-2134","source":"Crossref","is-referenced-by-count":26,"title":["Role of medial cortical networks for anticipatory processing in obsessive\u2010compulsive disorder"],"prefix":"10.1002","volume":"33","author":[{"given":"Kristina T.","family":"Ciesielski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott L.","family":"Rauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo P.","family":"Ahlfors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark 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