{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T05:16:32Z","timestamp":1697001392986},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,10,22]],"date-time":"2011-10-22T00:00:00Z","timestamp":1319241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Advantageous economic decision making requires flexible adaptation of gain\u2010based and loss\u2010based preference hierarchies. However, where the neuronal blueprints for economic preference hierarchies are kept and how they may be adapted remains largely unclear. Phasic cortical dopamine release likely mediates flexible adaptation of neuronal representations. In this PET study, cortical\u2010binding potential (BP) for the D<jats:sub>2<\/jats:sub>\u2010dopamine receptor ligand [<jats:sup>11<\/jats:sup>C]FLB 457 was examined in healthy participants during multiple sessions of a probabilistic four\u2010choice financial decision\u2010making task with two behavioral variants. In the <jats:italic>changing\u2010gains\/constant\u2010losses<\/jats:italic> variant, the implicit gain\u2010based preference hierarchy was unceasingly changing, whereas the implicit loss\u2010based preference hierarchy was constant. In the <jats:italic>constant\u2010gains\/changing\u2010losses<\/jats:italic> variant, it was the other way around. These variants served as paradigms, respectively, contrasting flexible adaptation versus maintenance of loss\u2010based and gain\u2010based preference hierarchies. We observed that in comparison with the <jats:italic>constant\u2010gains\/changing\u2010losses<\/jats:italic> variant, the <jats:italic>changing\u2010gains\/constant\u2010losses<\/jats:italic> variant was associated with a decreased D<jats:sub>2<\/jats:sub>\u2010dopamine receptor\u2010BP in the right lateral frontopolar cortex. In other words, lateral frontopolar D<jats:sub>2<\/jats:sub>\u2010dopamine receptor stimulation was specifically increased during continuous adaptation of mental representations of gain\u2010based preference hierarchies. This finding provides direct evidence for the existence of a neuronal blueprint of gain\u2010based decision\u2010making in the lateral frontopolar cortex and a crucial role of local dopamine in the flexible adaptation of mental concepts of future behavior. Hum Brain Mapp, 2013. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hbm.21425","type":"journal-article","created":{"date-parts":[[2011,10,22]],"date-time":"2011-10-22T08:26:37Z","timestamp":1319271997000},"page":"226-232","source":"Crossref","is-referenced-by-count":1,"title":["Prefrontal D2\u2010receptor stimulation mediates flexible adaptation of economic preference hierarchies"],"prefix":"10.1002","volume":"34","author":[{"given":"Thilo","family":"van Eimeren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji H.","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Pellechia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang 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